Anti-inflammatory actions of the neuroimmunomodulator α-MSH

α-melanocyte-stimulating hormone (α-MSH) is an endogenous neuroimmunomodulatory peptide that inhibits fever and all major forms of experimental inflammation. In humans, concentrations of α-MSH are increased a sites of inflammation, and in plasma in iniflammatory disorders and after injection of endotoxin. The effects of this ‘anti-cytokine’ peptide are mediated through α-MSH receptors and regulatory circuits in macrophages and neutrophils, and through descending neural anti-inflammatory pathways that originate from α-MSH receptors on neurons within the brain.