Dopamine may influence striatal GABA release via three separate mechanisms

We have examined the influence of dopamine (DA) on the spontaneous and electrically evoked release of γ-aminobutyric acid (GABA) from striatal slices prepared from rat brain. We observe that DA has at least 3 separate effects on GABA release. These effects include both excitatory and inhibitory infl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Brain research 1989-01, Vol.476 (2), p.373-376
Hauptverfasser:	Bernath, Sandor, Zigmond, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzazepines - pharmacology Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine Dopamine - pharmacology Electric Stimulation Ergolines - pharmacology Fundamental and applied biological sciences. Psychology gamma-Aminobutyric Acid - metabolism In vitro In Vitro Techniques Quinpirole Rats Receptors, Dopamine - drug effects Receptors, Dopamine - physiology Release Slice Striatum Sulpiride - pharmacology Uptake Vertebrates: nervous system and sense organs γ-Aminobutyric acid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We have examined the influence of dopamine (DA) on the spontaneous and electrically evoked release of γ-aminobutyric acid (GABA) from striatal slices prepared from rat brain. We observe that DA has at least 3 separate effects on GABA release. These effects include both excitatory and inhibitory influences, and involve DA receptors of the D 1- and D 2-subtypes as well as a mechanism that is not mediated by either of these receptors.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(89)91262-6