The physical and genetic map surrounding the Lyst gene on mouse Chromosome 13

The physical and genetic map surrounding the Lyst gene on mouse Chromosome 13

During the recent cloning of the mouse Lyst gene we developed both a high-resolution genetic map and a complete YAC and BAC contig of the Lyst critical region on mouse Chromosome 13. We also report the mapping of the human homologue of the mouse Lyst gene (LYST) to 1q43. These data are consistent wi...

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Veröffentlicht in:Genomics (San Diego, Calif.) Calif.), 1997-02, Vol.40 (1), p.147-150
Hauptverfasser: MISUMI, D. J, NAGLE, D. L, CARLSON, G. A, MOORE, K. J, MCGRAIL, S. H, DUSSAULT, B. J, SMUTKO, J. S, CHEN, H, CHARLAT, O, DUYK, G. M, EBELING, C, BALDINI, L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Base Sequence
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 1
Complex syndromes
DNA, Complementary
Female
Humans
Male
Medical genetics
Medical sciences
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Molecular Sequence Data
Proteins - genetics
Vesicular Transport Proteins
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Zusammenfassung:During the recent cloning of the mouse Lyst gene we developed both a high-resolution genetic map and a complete YAC and BAC contig of the Lyst critical region on mouse Chromosome 13. We also report the mapping of the human homologue of the mouse Lyst gene (LYST) to 1q43. These data are consistent with LYST being the gene for the human Chediak-Higashi Syndrome and strengthen the synteny relationship between MMU13 and human 1q43.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1996.4549