Brasiliquinones A, B and C, New Benz[a]anthraquinone Antibiotics from Nocardia brasiliensis: I. Producing Strain, Isolation and Biological Activities of the Antibiotics

New benz[a]anthraquinone antibiotics (brasiliquinones A, B and C) with an ethyl group at C-3 were isolated. The producer was identified as Nocardia brasiliensis. The antibiotics were active against Gram-positive bacteria including Mycobacterium sp., but not active against Gram-negative bacteria or f...

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Veröffentlicht in:	Journal of antibiotics 1997/01/25, Vol.50(1), pp.18-21
Hauptverfasser:	NEMOTO, AKIRA, TANAKA, YASUSHI, KARASAKI, YASUMI, KOMAKI, HISAYUKI, YAZAWA, KATSUKIYO, MIKAMI, YUZURU, TOJO, TAKASHI, KADOWAKI, KIYOSHI, TSUDA, MASASHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthraquinones - isolation & purification Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Fermentation Fundamental and applied biological sciences. Psychology Mice Microbiology Nocardia - classification Nocardia - metabolism Nocardia brasiliensis Tumor Cells, Cultured
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Zusammenfassung:	New benz[a]anthraquinone antibiotics (brasiliquinones A, B and C) with an ethyl group at C-3 were isolated. The producer was identified as Nocardia brasiliensis. The antibiotics were active against Gram-positive bacteria including Mycobacterium sp., but not active against Gram-negative bacteria or fungi. They were also active against multiple drug-resistant P388/ADR tumor cells.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.50.18