p53 and tumour viruses: Catching the guardian off-guard

Oncogenic viruses have evolved direct and indirect mechanisms to overcome the tumour suppressor p53. Fortunately, tumour development is limited by the narrow cell tropisms of the viruses concerned and the host immune response. However, such viruses are helping to elucidate the p53 response pathway a...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 1997-03, Vol.5 (3), p.115-120
Hauptverfasser:	Neil, James C., Cameron, Ewan R., Baxter, Euan W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Neoplasms - genetics Neoplasms - virology Oncogenic Viruses - immunology Oncogenic Viruses - physiology Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology
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Beschreibung
Zusammenfassung:	Oncogenic viruses have evolved direct and indirect mechanisms to overcome the tumour suppressor p53. Fortunately, tumour development is limited by the narrow cell tropisms of the viruses concerned and the host immune response. However, such viruses are helping to elucidate the p53 response pathway and may play a future role as novel cancer therapeutic agents.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/S0966-842X(96)10083-4