The pubertal spurt: effects of sex steroids on growth hormone and insulin-like growth factor I

In puberty, the growth spurt and the appearance of secondary sex characteristics occur concomitantly with an increase of sex steroids, growth hormone (GH) and insulin-like growth factor I (IGF-I). A number of experiments indicate that sex steroids exert a stimulatory action on the somatotropic axis....

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Veröffentlicht in:	European journal of obstetrics & gynecology and reproductive biology 1997-02, Vol.71 (2), p.215-217
1. Verfasser:	Caufriez, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Estradiol - metabolism Female Fundamental and applied biological sciences. Psychology Gonadal Steroid Hormones - metabolism Growth hormone Human Growth Hormone - metabolism Humans Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Neurosecretory Systems - physiology Oestrogens Pubertal spurt Puberty - physiology Secretory Rate - physiology Sexual differentiation and maturation. Puberty. Climacterium Testosterone Vertebrates: reproduction
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Beschreibung
Zusammenfassung:	In puberty, the growth spurt and the appearance of secondary sex characteristics occur concomitantly with an increase of sex steroids, growth hormone (GH) and insulin-like growth factor I (IGF-I). A number of experiments indicate that sex steroids exert a stimulatory action on the somatotropic axis. This effect is due to an amplifying action of oestradiol (secreted by the ovaries or after testosterone aromatization) on the neuroendocrine regulation of pulsatile GH release.
ISSN:	0301-2115 1872-7654
DOI:	10.1016/S0301-2115(96)02638-3