Cytotoxicity and electron microscopy of cell death induced by goniothalamin

Cytotoxicity and electron microscopy of cell death induced by goniothalamin

Abstract The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent....

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Veröffentlicht in:Planta medica 1997-02, Vol.63 (1), p.81-83
Hauptverfasser: Ali, A.M, Mackeen, M.M, Hamid, M, Aun, Q.B, Zauyah, Y, Azimahtol, H.L.P, Kawazu, K. (Malaysia Pertanian Univ., Selangor (Malaysia). Faculty of Food Science and Biotechnology. Dept. of Biotechnology)
Format: Artikel
Sprache:eng
Schlagworte:
3T3 Cells
Animals
Antineoplastic Agents, Phytogenic - pharmacology
BARK
Biological and medical sciences
Cell Death - drug effects
CHEMICAL COMPOSITION
CHEMICAL STRUCTURE
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CORTEZA
DRUG PLANTS
ECORCE
ESTRUCTURA QUIMICA
FARMACOLOGIA
General pharmacology
Humans
Letters
Medical sciences
Mice
Microscopy, Electron
NECROSE
NECROSIS
Pharmacognosy. Homeopathy. Health food
PHARMACOLOGIE
PHARMACOLOGY
Pharmacology. Drug treatments
PLANTAS MEDICINALES
PLANTE MEDICINALE
Pyrones - pharmacology
STRUCTURE CHIMIQUE
TOXINAS
TOXINE
TOXINS
Tumor Cells, Cultured
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Zusammenfassung:Abstract The cytotoxicity of goniothalamin was found to be strong towards both cancerous (HGC-27, MCF-7, PANC-1, HeLa), and non-cancerous (3T3) cell lines, especially in cases of dividing cells. Drug exposure studies indicated that the cytotoxic action of goniothalamin was time- and dose-dependent. At the ultra-structural level, goniothalamin-induced cytotoxicity revealed a necrotic mode of cell death towards MCF-7 cells.
ISSN:0032-0943
1439-0221
DOI:10.1055/s-2006-957611