Pigmented, Lipid-Laden Histiocytes in the Central Nervous System in Chronic Granulomatous Disease of Childhood

Pigmented, Lipid-Laden Histiocytes in the Central Nervous System in Chronic Granulomatous Disease of Childhood

In addition to granulomas, infiltrates of pigmented, lipid-laden histiocytes are a consistent morphologic finding in visceral organs of the reticuloendothelial system in patients with chronic granulomatous disease. We report a case with widespread meningeal and focal brain stem infiltrates of these...

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Veröffentlicht in:Journal of child neurology 1989-01, Vol.4 (1), p.61-63
Hauptverfasser: Riggs, Jack E., Quaglieri, Frank C., Schochet, Sydney S., Dove, Douglas J.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Central Nervous System - metabolism
Central Nervous System - pathology
Granulomatous Disease, Chronic - pathology
Histiocytes - metabolism
Histiocytes - pathology
Humans
Lipid Metabolism
Male
Pigmentation
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Zusammenfassung:In addition to granulomas, infiltrates of pigmented, lipid-laden histiocytes are a consistent morphologic finding in visceral organs of the reticuloendothelial system in patients with chronic granulomatous disease. We report a case with widespread meningeal and focal brain stem infiltrates of these distinctive histiocytes. The noninfectious involvement of the central nervous system in chronic granulomatous disease may be greater than previously recognized and related to the role of the CNS in the reticuloendothelial system. (J Child Neurol 1989;4:61-63).
ISSN:0883-0738
1708-8283
DOI:10.1177/088307388900400111