Long-term stepwise sustained improvement in left ventricular ejection fraction after myocardial infarction

Radionuclide left ventricular ejection fraction, end-diastolic volume, and exercise capacity were determined in 34 selected patients who survived a first Q wave anterior infarction. Patients were included in the study if they had no subsequent cardiac events (unstable angina or myocardial infarction) during the average follow-up period of 47 months (range = 36 to 70 months); none was treated with thrombolysis, coronary angioplasty, or bypass grafting. Overall, mean left ventricular ejection fraction increased from 28 ± 10% 1 month after infarction to 33 ± 10% at 3 years ( p < 0.01); mean end-diastolic volume decreased from 217 ± 99 ml to 171 ± 80 ml ( p < 0.002). Stepwise improvement in left ventricular ejection fraction occurred in 15 of these patients (group B) and was associated with a significant increase in exercise capacity. Mean ejection fraction in group B was 26 ± 7% at 1 month and 41 ± 10% at 3 years ( p < 0.001). In all of these patients there was improved regional wall motion in the noninfarct zone, whereas five patients also showed improvement in the infarct zone. The results indicate a progressive improvement in left ventricular function that occurs over time in some patients after first Q wave anterior infarction, independent of intervention.