Family of human Na +,K +-ATPase genes Structure of the putative regulatory region of the α +-gene

Family of human Na +,K +-ATPase genes Structure of the putative regulatory region of the α +-gene

The primary structure of the putative regulatory region of a gene of the Na +,K +-ATPase multigene family in the human genome has been determined. This region includes the first exon with all of the untranslatable sequence of mRNA and a dozen nucleotides, coding for the first four amino acids of the...

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Veröffentlicht in:FEBS letters 1989-02, Vol.244 (2), p.481-483
Hauptverfasser: Sverdlov, E.D., Bessarab, D.A., Malyshev, I.V., Petrukhin, K.E., Smirnov, Yu.V., Ushkaryov, Yu.A., Monastyrskaya, G.S., Broude, N.E., Modyanov, N.N.
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Animals
ATPase, Na +,K
Base Sequence
Cloning, Molecular
Cosmids
Gene sequence
Genes
Genes, Regulator
Humans
Mice
Molecular Sequence Data
Multigene Family
Rabbits
Regulatory region
Restriction Mapping
Sequence Homology, Nucleic Acid
Sodium-Potassium-Exchanging ATPase - genetics
Subunit, α +-catalytic
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Zusammenfassung:The primary structure of the putative regulatory region of a gene of the Na +,K +-ATPase multigene family in the human genome has been determined. This region includes the first exon with all of the untranslatable sequence of mRNA and a dozen nucleotides, coding for the first four amino acids of the hypothetic precursor of the α +-subunit. The entire region comprises over 1400 bp. The possible role of specific nucleotide blocks within this region in comparison with other genes is discussed.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(89)80588-5