Predisposing locus for Alzheimer's disease on chromosome 21

Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that t...

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Veröffentlicht in:	The Lancet (British edition) 1989-02, Vol.1 (8634), p.352-355
Hauptverfasser:	Goate, A M, Haynes, A R, Owen, M J, Farrall, M, James, L A, Lai, L Y, Mullan, M J, Roques, P, Rossor, M N, Williamson, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Alzheimer Disease - genetics Blotting, Southern Chromosome Aberrations - genetics Chromosome Disorders Chromosome Mapping Chromosomes, Human, Pair 21 Female Genetic Linkage Humans Male Middle Aged Mutation Polymorphism, Restriction Fragment Length Recombination, Genetic
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Linkage between Alzheimer's disease and markers on the long arm of chromosome 21 was investigated in six families affected by disease of early onset. Linkage was confirmed and the disease locus shown to be centromeric to the locus D21S1/S11 on the long arm of the chromosome. It is argued that the data are consistent with the notion that all patients with Alzheimer's disease of genetic aetiology have a predisposing locus on chromosome 21.
ISSN:	0140-6736