Morphotype markers of virulence in human candidal infections

Division of Hospital Infection * Mycological Reference Laboratory, Central Public Health Laboratory, 61 Colindale Avenue, London NW9 5HT Received February 11, 1988 Accepted May 20, 1988 A study of the morphotypes of 446 strains of Candida albicans , isolated from a variety of clinical specimens, is reported. The method was based on a morphotyping scheme that has recently been described, but not all of the potential characters were used in this analysis. By this limited code, 50 different morphotypes were distinguished, the largest group comprising 23% of the population. The simplicity and good discrimination of the method make it a useful typing scheme for C. albicans . Discontinuous colonial fringes were associated with strains from oral sites and deep infections. Significantly, 67% of strains from fatal infections were of the discontinuous fringe type, compared to only 11% of strains from other infections. Further associations between morphotype and anatomical source included narrow-coarse fringes in genitourinary isolates.