Antineoplastic Agents. 362. Isolation and X-ray Crystal Structure of Dibromophakellstatin from the Indian Ocean Sponge Phakellia mauritiana

Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized....

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 1997-02, Vol.60 (2), p.180-183
Hauptverfasser:	Pettit, George R, McNulty, James, Herald, Delbert L, Doubek, Dennis L, Chapuis, Jean-Charles, Schmidt, Jean M, Tackett, Larry P, Boyd, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	AGENTES ANTINEOPLASTICOS Animals ANTINEOPLASTIC AGENTS Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology BIOASSAYS Biological and medical sciences CELL CULTURE CELL LINES CHEMICAL COMPOSITION CHEMICAL STRUCTURE CHEMISTRY CHIMIE COMPOSE HETEROCYCLIQUE COMPOSE ORGANOAZOTE COMPOSICION QUIMICA COMPOSITION CHIMIQUE COMPUESTO ORGANICO DEL NITROGENO COMPUESTOS HETEROCICLICOS Crystallography, X-Ray CULTIVO DE CELULAS CULTURE DE CELLULE CYTOTOXIC COMPOUNDS DEBROMOHYMENIALOSINE DEOXYRIBONUCLEOSIDE DEOXYRIBONUCLEOSIDES DEOXYURIDINE DESOXIRIBONUCLEOSIDOS DIBROMOPHAKELLIN DOSAGE BIOLOGIQUE Drug Screening Assays, Antitumor ENSAYO BIOLOGICO ESPECTROMETRIA ESTRUCTURA QUIMICA General pharmacology HETEROCYCLIC COMPOUNDS HUMAN TUMOR CELL LINES Humans Imidazoles - chemistry Imidazoles - isolation & purification Imidazoles - pharmacology INDIAN OCEAN Marine Medical sciences MEDICAMENT CYTOSTATIQUE Molecular Structure OCEAN INDIEN OCEANO INDICO ORGANIC NITROGEN COMPOUNDS PARAZOA Phakellia mauritiana Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera Porifera - chemistry QUIMICA SEYCHELLES SPECTRAL ANALYSIS SPECTROMETRIE SPECTROMETRY STEREOCHEMISTRY STRUCTURE CHIMIQUE SUBSTANCE TOXIQUE SUSTANCIAS TOXICAS THYMIDINE THYMINE TIMIDINA TIMINA TOXIC SUBSTANCES Tumor Cells, Cultured
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Zusammenfassung:	Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia mauritiana. The isolation, X-ray crystal structure elucidation, absolute stereochemistry, and antineoplastic activity have been summarized. P. mauritiana was also found to contain dibromophakellin (1), debromohymenialosine (2), thymidine, deoxyuridine, and thymine.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np9606106