Decreased plasma tryptophan levels in major depression

Total plasma tryptophan was significantly lower in 12 depressed patients than in 12 normal controls. The ratio of total tryptophan to neutral amino acids was also decreased in the depressed patients suggesting that tryptophan availability to the brain might be reduced. There was no correlation betwe...

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Veröffentlicht in:	Journal of affective disorders 1989, Vol.16 (1), p.27-31
Hauptverfasser:	Cowen, P.J., Parry-Billings, M., Newsholme, E.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptamine Adult Biological and medical sciences Depression Depressive Disorder - blood Female Growth hormone Growth Hormone - blood Humans Isoleucine - blood Leucine - blood Male Medical sciences Middle Aged Miscellaneous Neutral amino acids Prolactin Prolactin - blood Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Techniques and methods Tryptophan Tryptophan - blood Tyrosine - blood Valine - blood
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Zusammenfassung:	Total plasma tryptophan was significantly lower in 12 depressed patients than in 12 normal controls. The ratio of total tryptophan to neutral amino acids was also decreased in the depressed patients suggesting that tryptophan availability to the brain might be reduced. There was no correlation between basal tryptophan concentrations in the depressed subjects and the subsequent neuroendocrine response to intravenous tryptophan.
ISSN:	0165-0327 1573-2517
DOI:	10.1016/0165-0327(89)90051-7