Genetic variation of haptoglobin and transferrin in relation to DNA content and stage in renal cell carcinoma

Four genetic marker systems were investigated in 102 patients with renal cell carcinoma. The previously observed excess of the transferrin (TF) variant C3 among male patients was confirmed. Interestingly, an excess of TFC3 and a deficit of the haptoglobin heterozygote, HP2–1, were associated with di...

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Veröffentlicht in:	Cancer 1989-03, Vol.63 (6), p.1138-1142
Hauptverfasser:	Fröhlander, Nils, Ljungberg, Börje, Roos, Göran
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma, Renal Cell - analysis Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Complement C3 - analysis Diploidy DNA, Neoplasm - analysis Female Genetic Markers - analysis Haptoglobins - genetics Humans Kidney Neoplasms - analysis Kidney Neoplasms - genetics Kidney Neoplasms - pathology Kidneys Male Medical sciences Neoplasm Staging Nephrology. Urinary tract diseases Phenotype Transferrin - genetics Tumors of the urinary system Vitamin D-Binding Protein - analysis
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Zusammenfassung:	Four genetic marker systems were investigated in 102 patients with renal cell carcinoma. The previously observed excess of the transferrin (TF) variant C3 among male patients was confirmed. Interestingly, an excess of TFC3 and a deficit of the haptoglobin heterozygote, HP2–1, were associated with diploid tumor DNA content and Stage I, particularly in male patients. The results are discussed in terms of a possible genetic influence on tumor progression.
ISSN:	0008-543X 1097-0142
DOI:	10.1002/1097-0142(19890315)63:6<1138::AID-CNCR2820630616>3.0.CO;2-P