Pax-6 in development and evolution

Pax-6 is a member of the Pax gene class and encodes a protein containing a paired domain and a homeodomain. The molecular characterization of Pax-6 genes from species of different animal phyla and the analysis of Pax-6 function in the developing eyes and central nervous system of vertebrates, Drosop...

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Veröffentlicht in:	Annual review of neuroscience 1997-01, Vol.20 (1), p.483-532
Hauptverfasser:	CALLAERTS, P, HALDER, G, GEHRING, W. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Evolution Development. Senescence. Regeneration. Transplantation DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Eye Proteins Fundamental and applied biological sciences. Psychology Homeodomain Proteins Paired Box Transcription Factors PAX6 Transcription Factor Repressor Proteins Transcription Factors - metabolism Transcription Factors - physiology Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Pax-6 is a member of the Pax gene class and encodes a protein containing a paired domain and a homeodomain. The molecular characterization of Pax-6 genes from species of different animal phyla and the analysis of Pax-6 function in the developing eyes and central nervous system of vertebrates, Drosophila melanogaster, and Caenorhabditis elegans suggest that Pax-6 homologues share conserved functions. In this review, we present recent data on the structural and functional characterization of Pax-6 homologues from species of different animal phyla. We discuss the implications of these findings for our understanding of the development and evolution of eyes and nervous systems.
ISSN:	0147-006X 1545-4126
DOI:	10.1146/annurev.neuro.20.1.483