A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells

An enzyme in homogenates of porcine vascular endothelial cells forms L-citrulline from L-arginine. This enzyme is soluble and NADPH-dependent. In addition, the enzyme is inhibited by N G-monomethyl-L-arginine, suggesting that it is involved in the formation of nitric oxide by vascular endothelial ce...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 1989-01, Vol.158 (1), p.348-352
Hauptverfasser:	Palmer, Richard M.J., Moncada, Salvador
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Aorta, Thoracic Arginine - metabolism Biological and medical sciences blood vessels Cells, Cultured citrulline Citrulline - biosynthesis Endothelium, Vascular - enzymology Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology General aspects, investigation methods nitric oxide Nitric Oxide - metabolism Swine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	An enzyme in homogenates of porcine vascular endothelial cells forms L-citrulline from L-arginine. This enzyme is soluble and NADPH-dependent. In addition, the enzyme is inhibited by N G-monomethyl-L-arginine, suggesting that it is involved in the formation of nitric oxide by vascular endothelial cells.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/S0006-291X(89)80219-0