Chronic eosinophilic leukaemia (CEL): a distinct myeloproliferative disease
Chronic eosinophilic leukaemia has not yet been clearly defined, mainly due to the fact that it has not been conclusively shown as a monoclonal disease which should be separated from chronic myelogenous leukaemia, acute myelogenous leukaemia with eosinophilia (AML, FAB M4Eo), and the idiopathic hype...
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| Veröffentlicht in: | British journal of haematology 1997-01, Vol.96 (1), p.117-123 |
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| container_title | British journal of haematology |
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| creator | Weide, Rudolf Rieder, Harald Mehraein, Yasemien Wolf, Martin Kaiser, Ulrich Seifart, Ulf Görg, Christian Havemann, Klaus |
| description | Chronic eosinophilic leukaemia has not yet been clearly defined, mainly due to the fact that it has not been conclusively shown as a monoclonal disease which should be separated from chronic myelogenous leukaemia, acute myelogenous leukaemia with eosinophilia (AML, FAB M4Eo), and the idiopathic hypereosinophilic syndrome.
We report a patient with a white blood cell count of 17.6 × 109/l with 74% eosinophils, normal platelet count and haemoglobin. No blasts were seen in the peripheral blood and the percentage of blasts in the bone marrow was |
| doi_str_mv | 10.1046/j.1365-2141.1997.d01-1991.x |
| format | Article |
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We report a patient with a white blood cell count of 17.6 × 109/l with 74% eosinophils, normal platelet count and haemoglobin. No blasts were seen in the peripheral blood and the percentage of blasts in the bone marrow was <3%. A diagnosis of chronic eosinophilic leukaemia was made. Chromosome analysis of a bone marrow aspirate disclosed a trisomy 15 together with loss of the Y chromosome. Moreover, FISH analysis on May‐Grünwald‐Giemsa‐stained peripheral blood smears demonstrated trisomy 15 in the eosinophils. 3 months after initial diagnosis the patient went into blast crisis and died. The blast cells exhibited trisomy 15 and loss of the Y chromosome in a complex, aberrant karyotype.
In conclusion, the case shows that chronic eosinophilic leukaemia is a monoclonal, myeloproliferative disease with eosinophils as part of the malignant clone. Clinically, chronic eosinophilic leukaemia can be separated into a chronic phase and a blast crisis.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.1997.d01-1991.x</identifier><identifier>PMID: 9012697</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Blast Crisis ; Chromosomes, Human, Pair 15 ; Chronic Disease ; chronic eosinophilic leukaemia ; Fatal Outcome ; Hematologic and hematopoietic diseases ; Humans ; Hypereosinophilic Syndrome - blood ; Hypereosinophilic Syndrome - diagnosis ; Hypereosinophilic Syndrome - genetics ; In Situ Hybridization, Fluorescence ; Karyotyping ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukocyte Count ; Male ; Medical sciences ; Middle Aged ; monoclonal ; myeloproliferative disease ; Platelet Count ; Trisomy</subject><ispartof>British journal of haematology, 1997-01, Vol.96 (1), p.117-123</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4548-d77ed636ad82c489c1ff4793a6c7d81630fbda61d1bec950d0af2f0228a2561c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2141.1997.d01-1991.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2141.1997.d01-1991.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,4024,27923,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2543504$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9012697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weide, Rudolf</creatorcontrib><creatorcontrib>Rieder, Harald</creatorcontrib><creatorcontrib>Mehraein, Yasemien</creatorcontrib><creatorcontrib>Wolf, Martin</creatorcontrib><creatorcontrib>Kaiser, Ulrich</creatorcontrib><creatorcontrib>Seifart, Ulf</creatorcontrib><creatorcontrib>Görg, Christian</creatorcontrib><creatorcontrib>Havemann, Klaus</creatorcontrib><title>Chronic eosinophilic leukaemia (CEL): a distinct myeloproliferative disease</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Chronic eosinophilic leukaemia has not yet been clearly defined, mainly due to the fact that it has not been conclusively shown as a monoclonal disease which should be separated from chronic myelogenous leukaemia, acute myelogenous leukaemia with eosinophilia (AML, FAB M4Eo), and the idiopathic hypereosinophilic syndrome.
We report a patient with a white blood cell count of 17.6 × 109/l with 74% eosinophils, normal platelet count and haemoglobin. No blasts were seen in the peripheral blood and the percentage of blasts in the bone marrow was <3%. A diagnosis of chronic eosinophilic leukaemia was made. Chromosome analysis of a bone marrow aspirate disclosed a trisomy 15 together with loss of the Y chromosome. Moreover, FISH analysis on May‐Grünwald‐Giemsa‐stained peripheral blood smears demonstrated trisomy 15 in the eosinophils. 3 months after initial diagnosis the patient went into blast crisis and died. The blast cells exhibited trisomy 15 and loss of the Y chromosome in a complex, aberrant karyotype.
In conclusion, the case shows that chronic eosinophilic leukaemia is a monoclonal, myeloproliferative disease with eosinophils as part of the malignant clone. Clinically, chronic eosinophilic leukaemia can be separated into a chronic phase and a blast crisis.</description><subject>Biological and medical sciences</subject><subject>Blast Crisis</subject><subject>Chromosomes, Human, Pair 15</subject><subject>Chronic Disease</subject><subject>chronic eosinophilic leukaemia</subject><subject>Fatal Outcome</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Hypereosinophilic Syndrome - blood</subject><subject>Hypereosinophilic Syndrome - diagnosis</subject><subject>Hypereosinophilic Syndrome - genetics</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Karyotyping</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>monoclonal</subject><subject>myeloproliferative disease</subject><subject>Platelet Count</subject><subject>Trisomy</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1r2zAUhsVYadNuP6Fg2CjthT0dy5bk7aK0oR_bArvZroUiHVFlsp1aSZv8-8ok5L5XOuJ9XunwEPIFaAG04t8WBTBe5yVUUEDTiMJSyNMAxeYDmRyyj2RCKRV56sgTchrjglJgtIZjctxQKHkjJuT39GnoO28y7KPv-uWTD-kScP1fY-t1djm9m119z3RmfVz5zqyydouhXw598A4HvfIvOGaoI34iR06HiJ_35xn5d3_3d_qYz_48_JzezHJT1ZXMrRBoOePaytJUsjHgXCUaprkRVgJn1M2t5mBhjqapqaXalY6WpdRlzcGwM3Kxezdt8bzGuFKtjwZD0B3266iElCBYzRL4YweaoY9xQKeWg2_1sFVA1ahSLdSoS4261KhSJZXjAGqT2uf7b9bzFu2hu3eX8q_7XEejgxt0Z3w8YGVdsZpWCbveYa8-4PY9G6jbX4-SS_YGAs6QUA</recordid><startdate>199701</startdate><enddate>199701</enddate><creator>Weide, Rudolf</creator><creator>Rieder, Harald</creator><creator>Mehraein, Yasemien</creator><creator>Wolf, Martin</creator><creator>Kaiser, Ulrich</creator><creator>Seifart, Ulf</creator><creator>Görg, Christian</creator><creator>Havemann, Klaus</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199701</creationdate><title>Chronic eosinophilic leukaemia (CEL): a distinct myeloproliferative disease</title><author>Weide, Rudolf ; Rieder, Harald ; Mehraein, Yasemien ; Wolf, Martin ; Kaiser, Ulrich ; Seifart, Ulf ; Görg, Christian ; Havemann, Klaus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4548-d77ed636ad82c489c1ff4793a6c7d81630fbda61d1bec950d0af2f0228a2561c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Blast Crisis</topic><topic>Chromosomes, Human, Pair 15</topic><topic>Chronic Disease</topic><topic>chronic eosinophilic leukaemia</topic><topic>Fatal Outcome</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Hypereosinophilic Syndrome - blood</topic><topic>Hypereosinophilic Syndrome - diagnosis</topic><topic>Hypereosinophilic Syndrome - genetics</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Karyotyping</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>monoclonal</topic><topic>myeloproliferative disease</topic><topic>Platelet Count</topic><topic>Trisomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weide, Rudolf</creatorcontrib><creatorcontrib>Rieder, Harald</creatorcontrib><creatorcontrib>Mehraein, Yasemien</creatorcontrib><creatorcontrib>Wolf, Martin</creatorcontrib><creatorcontrib>Kaiser, Ulrich</creatorcontrib><creatorcontrib>Seifart, Ulf</creatorcontrib><creatorcontrib>Görg, Christian</creatorcontrib><creatorcontrib>Havemann, Klaus</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weide, Rudolf</au><au>Rieder, Harald</au><au>Mehraein, Yasemien</au><au>Wolf, Martin</au><au>Kaiser, Ulrich</au><au>Seifart, Ulf</au><au>Görg, Christian</au><au>Havemann, Klaus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic eosinophilic leukaemia (CEL): a distinct myeloproliferative disease</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>1997-01</date><risdate>1997</risdate><volume>96</volume><issue>1</issue><spage>117</spage><epage>123</epage><pages>117-123</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Chronic eosinophilic leukaemia has not yet been clearly defined, mainly due to the fact that it has not been conclusively shown as a monoclonal disease which should be separated from chronic myelogenous leukaemia, acute myelogenous leukaemia with eosinophilia (AML, FAB M4Eo), and the idiopathic hypereosinophilic syndrome.
We report a patient with a white blood cell count of 17.6 × 109/l with 74% eosinophils, normal platelet count and haemoglobin. No blasts were seen in the peripheral blood and the percentage of blasts in the bone marrow was <3%. A diagnosis of chronic eosinophilic leukaemia was made. Chromosome analysis of a bone marrow aspirate disclosed a trisomy 15 together with loss of the Y chromosome. Moreover, FISH analysis on May‐Grünwald‐Giemsa‐stained peripheral blood smears demonstrated trisomy 15 in the eosinophils. 3 months after initial diagnosis the patient went into blast crisis and died. The blast cells exhibited trisomy 15 and loss of the Y chromosome in a complex, aberrant karyotype.
In conclusion, the case shows that chronic eosinophilic leukaemia is a monoclonal, myeloproliferative disease with eosinophils as part of the malignant clone. Clinically, chronic eosinophilic leukaemia can be separated into a chronic phase and a blast crisis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>9012697</pmid><doi>10.1046/j.1365-2141.1997.d01-1991.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Blast Crisis Chromosomes, Human, Pair 15 Chronic Disease chronic eosinophilic leukaemia Fatal Outcome Hematologic and hematopoietic diseases Humans Hypereosinophilic Syndrome - blood Hypereosinophilic Syndrome - diagnosis Hypereosinophilic Syndrome - genetics In Situ Hybridization, Fluorescence Karyotyping Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocyte Count Male Medical sciences Middle Aged monoclonal myeloproliferative disease Platelet Count Trisomy |
| title | Chronic eosinophilic leukaemia (CEL): a distinct myeloproliferative disease |
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