The role of water in protein—DNA interactions

The role of water in protein—DNA interactions

It is becoming well accepted that water plays an important role in both the specificity and affinity of protein—DNA interactions. Recently, a combination of structural, biochemical and thermodynamic techniques has particularly enhanced our understanding of the role of water in complexes between DNA...

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Veröffentlicht in:Current opinion in structural biology 1997-02, Vol.7 (1), p.126-134
1. Verfasser: Schwabe, John WR
Format: Artikel
Sprache:eng
Schlagworte:
DNA - metabolism
DNA-Binding Proteins - chemistry
DNA-Binding Proteins - metabolism
Thermodynamics
Water - chemistry
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Beschreibung
Zusammenfassung:It is becoming well accepted that water plays an important role in both the specificity and affinity of protein—DNA interactions. Recently, a combination of structural, biochemical and thermodynamic techniques has particularly enhanced our understanding of the role of water in complexes between DNA and three different proteins: the trp repressor; the homeodomain; and the glucocorticoid receptor DNA-binding domain.
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(97)80016-4