Apoptosis in murine cardiac grafts

Apoptosis, or the induction of programmed cell death, is a mechanism commonly used by cytotoxic T cells to cause target cell lysis. We evaluated the frequency and distribution of apoptotic cells in DBA/2-->DBA/2 heterotopic cardiac isografts, acutely rejecting DBA/2-->C57BL/6 cardiac allograft...

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Veröffentlicht in:	Transplantation 1997-01, Vol.63 (2), p.320-325
Hauptverfasser:	BERGESE, S. D, KLENOTIC, S. M, WAKELY, M. E, SEDMAK, D. D, OROSZ, C. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences DNA Damage Female Graft Rejection - immunology Graft Rejection - pathology Heart Transplantation - immunology Heart Transplantation - pathology Medical sciences Mice Mice, Inbred C57BL Mice, Inbred DBA Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart T-Lymphocytes, Cytotoxic - immunology Transplantation, Heterotopic Transplantation, Homologous Transplantation, Isogeneic
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Zusammenfassung:	Apoptosis, or the induction of programmed cell death, is a mechanism commonly used by cytotoxic T cells to cause target cell lysis. We evaluated the frequency and distribution of apoptotic cells in DBA/2-->DBA/2 heterotopic cardiac isografts, acutely rejecting DBA/2-->C57BL/6 cardiac allografts, and accepted, 60 day DBA/2-->C57BL/6 allografts from mice treated with anti-CD4 Mab (GK1.5) or gallium nitrate (GN). Apoptosis was identified in histologic sections via TUNEL analysis of nuclear DNA fragmentation. We observed the following. (1) Cardiac isografts display no detectable TUNEL+ cells. (2) Rejecting cardiac allografts display rare (
ISSN:	0041-1337 1534-6080
DOI:	10.1097/00007890-199701270-00025