The effect of sequential three-monthly hormone replacement therapy on several cardiovascular risk estimators in postmenopausal women
To investigate the changes in plasma lipids and lipoproteins, low-density lipoprotein (LDL) oxidizability, and plasma homocysteine during postmenopausal sequential 3-monthly hormone replacement therapy. Open longitudinal prospective study. Gynecological outpatient department of a university hospital...
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| Veröffentlicht in: | Fertility and sterility 1997, Vol.67 (1), p.67-73 |
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| container_title | Fertility and sterility |
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| creator | van der Mooren, Marius J. Demacker, Pierre N.M. Blom, Henk J. de Rijke, Yolanda B. Rolland, Rune |
| description | To investigate the changes in plasma lipids and lipoproteins, low-density lipoprotein (LDL) oxidizability, and plasma homocysteine during postmenopausal sequential 3-monthly hormone replacement therapy.
Open longitudinal prospective study.
Gynecological outpatient department of a university hospital.
Thirty-nine healthy nonhysterectomized postmenopausal women.
Oral conjugated estrogen, 0.625 mg/d, combined with oral medrogestone 10 mg/d during the last 14 days of each 84-day treatment cycle. The treatment was given for four treatment cycles of 84 days (1 year).
Plasma lipids and lipoproteins, LDL oxidizability, and plasma homocysteine.
After 1 year of treatment plasma concentrations of total cholesterol and LDL cholesterol were 3.5% and 8.7% lower, respectively. High density lipoprotein cholesterol, apolipoprotein A-I, and triglycerides were 6.5%, 9.0% and 16% higher, respectively. Apolipoprotein B concentration remained unchanged. The results on LDL oxidizability were inconsistent. Plasma homocysteine decreased with 12.3% during the first 6 months of treatment in women with higher homocysteine concentrations at baseline. These values returned to baseline levels during the second half year of treatment.
This sequential hormone regimen induced beneficial changes in the conventional lipid and lipoprotein risk estimators, whereas the observed changes in the other markers remained inconclusive and/or of minor importance. |
| doi_str_mv | 10.1016/S0015-0282(97)81858-4 |
| format | Article |
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Open longitudinal prospective study.
Gynecological outpatient department of a university hospital.
Thirty-nine healthy nonhysterectomized postmenopausal women.
Oral conjugated estrogen, 0.625 mg/d, combined with oral medrogestone 10 mg/d during the last 14 days of each 84-day treatment cycle. The treatment was given for four treatment cycles of 84 days (1 year).
Plasma lipids and lipoproteins, LDL oxidizability, and plasma homocysteine.
After 1 year of treatment plasma concentrations of total cholesterol and LDL cholesterol were 3.5% and 8.7% lower, respectively. High density lipoprotein cholesterol, apolipoprotein A-I, and triglycerides were 6.5%, 9.0% and 16% higher, respectively. Apolipoprotein B concentration remained unchanged. The results on LDL oxidizability were inconsistent. Plasma homocysteine decreased with 12.3% during the first 6 months of treatment in women with higher homocysteine concentrations at baseline. These values returned to baseline levels during the second half year of treatment.
This sequential hormone regimen induced beneficial changes in the conventional lipid and lipoprotein risk estimators, whereas the observed changes in the other markers remained inconclusive and/or of minor importance.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(97)81858-4</identifier><identifier>PMID: 8986686</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Biological and medical sciences ; Cardiovascular Diseases - prevention & control ; estrogen ; Estrogen Replacement Therapy ; Estrogens, Conjugated (USP) - administration & dosage ; Female ; homocysteine ; Homocysteine - blood ; Hormones. Endocrine system ; Humans ; LDL oxidizability ; lipids ; Lipids - blood ; lipoproteins ; Longitudinal Studies ; Medical sciences ; Middle Aged ; Oxidation-Reduction ; Pharmacology. Drug treatments ; Postmenopause ; progestogen ; Prospective Studies</subject><ispartof>Fertility and sterility, 1997, Vol.67 (1), p.67-73</ispartof><rights>1997 American Society for Reproductive Medicine</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-3611148d3a02f7846457ac0b916ce1f802a24b6dda68497485c7ff4cdc363c4a3</citedby><cites>FETCH-LOGICAL-c436t-3611148d3a02f7846457ac0b916ce1f802a24b6dda68497485c7ff4cdc363c4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028297818584$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2526129$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8986686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Mooren, Marius J.</creatorcontrib><creatorcontrib>Demacker, Pierre N.M.</creatorcontrib><creatorcontrib>Blom, Henk J.</creatorcontrib><creatorcontrib>de Rijke, Yolanda B.</creatorcontrib><creatorcontrib>Rolland, Rune</creatorcontrib><title>The effect of sequential three-monthly hormone replacement therapy on several cardiovascular risk estimators in postmenopausal women</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To investigate the changes in plasma lipids and lipoproteins, low-density lipoprotein (LDL) oxidizability, and plasma homocysteine during postmenopausal sequential 3-monthly hormone replacement therapy.
Open longitudinal prospective study.
Gynecological outpatient department of a university hospital.
Thirty-nine healthy nonhysterectomized postmenopausal women.
Oral conjugated estrogen, 0.625 mg/d, combined with oral medrogestone 10 mg/d during the last 14 days of each 84-day treatment cycle. The treatment was given for four treatment cycles of 84 days (1 year).
Plasma lipids and lipoproteins, LDL oxidizability, and plasma homocysteine.
After 1 year of treatment plasma concentrations of total cholesterol and LDL cholesterol were 3.5% and 8.7% lower, respectively. High density lipoprotein cholesterol, apolipoprotein A-I, and triglycerides were 6.5%, 9.0% and 16% higher, respectively. Apolipoprotein B concentration remained unchanged. The results on LDL oxidizability were inconsistent. Plasma homocysteine decreased with 12.3% during the first 6 months of treatment in women with higher homocysteine concentrations at baseline. These values returned to baseline levels during the second half year of treatment.
This sequential hormone regimen induced beneficial changes in the conventional lipid and lipoprotein risk estimators, whereas the observed changes in the other markers remained inconclusive and/or of minor importance.</description><subject>Biological and medical sciences</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>estrogen</subject><subject>Estrogen Replacement Therapy</subject><subject>Estrogens, Conjugated (USP) - administration & dosage</subject><subject>Female</subject><subject>homocysteine</subject><subject>Homocysteine - blood</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>LDL oxidizability</subject><subject>lipids</subject><subject>Lipids - blood</subject><subject>lipoproteins</subject><subject>Longitudinal Studies</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oxidation-Reduction</subject><subject>Pharmacology. Drug treatments</subject><subject>Postmenopause</subject><subject>progestogen</subject><subject>Prospective Studies</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEURonRjD2jjzAJC2N0UQoUf7UyZqKjySQuHNeEpi5plCpKoNr03geXme701hWX3PMB94DQNSXvKKHy_XdCqOgI0-zNoN5qqoXu-BO0oULITkjRP0WbM_IcXZbykxAiqWIX6EIPWkotN-jv_Q4weA-u4uRxgd8rzDXYiOsuA3RTmusuHvAu5VYCzrBE62BqUCMg2-WA09xy-1ZH7GweQ9rb4tZoM86h_MJQaphsTbngMOMlldrSabFraYE_qW1eoGfexgIvT-sV-vH50_3Nl-7u2-3Xm493neO9rF0vKaVcj70lzCvNJRfKOrIdqHRAvSbMMr6V42il5oPiWjjlPXej62XvuO2v0OvjuUtObc5SzRSKgxjtDGktRmk1EMZkA8URdDmVksGbJbcZ8sFQYh7sm0f75kGtGZR5tG94y12fLli3E4zn1El367869ZshG322swvljDHBJGVDwz4cMWgy9gGyKS7A7GAMuX2UGVP4z0P-AcjqpIM</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>van der Mooren, Marius J.</creator><creator>Demacker, Pierre N.M.</creator><creator>Blom, Henk J.</creator><creator>de Rijke, Yolanda B.</creator><creator>Rolland, Rune</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>The effect of sequential three-monthly hormone replacement therapy on several cardiovascular risk estimators in postmenopausal women</title><author>van der Mooren, Marius J. ; Demacker, Pierre N.M. ; Blom, Henk J. ; de Rijke, Yolanda B. ; Rolland, Rune</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-3611148d3a02f7846457ac0b916ce1f802a24b6dda68497485c7ff4cdc363c4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>estrogen</topic><topic>Estrogen Replacement Therapy</topic><topic>Estrogens, Conjugated (USP) - administration & dosage</topic><topic>Female</topic><topic>homocysteine</topic><topic>Homocysteine - blood</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>LDL oxidizability</topic><topic>lipids</topic><topic>Lipids - blood</topic><topic>lipoproteins</topic><topic>Longitudinal Studies</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oxidation-Reduction</topic><topic>Pharmacology. Drug treatments</topic><topic>Postmenopause</topic><topic>progestogen</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Mooren, Marius J.</creatorcontrib><creatorcontrib>Demacker, Pierre N.M.</creatorcontrib><creatorcontrib>Blom, Henk J.</creatorcontrib><creatorcontrib>de Rijke, Yolanda B.</creatorcontrib><creatorcontrib>Rolland, Rune</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Mooren, Marius J.</au><au>Demacker, Pierre N.M.</au><au>Blom, Henk J.</au><au>de Rijke, Yolanda B.</au><au>Rolland, Rune</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of sequential three-monthly hormone replacement therapy on several cardiovascular risk estimators in postmenopausal women</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1997</date><risdate>1997</risdate><volume>67</volume><issue>1</issue><spage>67</spage><epage>73</epage><pages>67-73</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>To investigate the changes in plasma lipids and lipoproteins, low-density lipoprotein (LDL) oxidizability, and plasma homocysteine during postmenopausal sequential 3-monthly hormone replacement therapy.
Open longitudinal prospective study.
Gynecological outpatient department of a university hospital.
Thirty-nine healthy nonhysterectomized postmenopausal women.
Oral conjugated estrogen, 0.625 mg/d, combined with oral medrogestone 10 mg/d during the last 14 days of each 84-day treatment cycle. The treatment was given for four treatment cycles of 84 days (1 year).
Plasma lipids and lipoproteins, LDL oxidizability, and plasma homocysteine.
After 1 year of treatment plasma concentrations of total cholesterol and LDL cholesterol were 3.5% and 8.7% lower, respectively. High density lipoprotein cholesterol, apolipoprotein A-I, and triglycerides were 6.5%, 9.0% and 16% higher, respectively. Apolipoprotein B concentration remained unchanged. The results on LDL oxidizability were inconsistent. Plasma homocysteine decreased with 12.3% during the first 6 months of treatment in women with higher homocysteine concentrations at baseline. These values returned to baseline levels during the second half year of treatment.
This sequential hormone regimen induced beneficial changes in the conventional lipid and lipoprotein risk estimators, whereas the observed changes in the other markers remained inconclusive and/or of minor importance.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8986686</pmid><doi>10.1016/S0015-0282(97)81858-4</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Cardiovascular Diseases - prevention & control estrogen Estrogen Replacement Therapy Estrogens, Conjugated (USP) - administration & dosage Female homocysteine Homocysteine - blood Hormones. Endocrine system Humans LDL oxidizability lipids Lipids - blood lipoproteins Longitudinal Studies Medical sciences Middle Aged Oxidation-Reduction Pharmacology. Drug treatments Postmenopause progestogen Prospective Studies |
| title | The effect of sequential three-monthly hormone replacement therapy on several cardiovascular risk estimators in postmenopausal women |
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