How Cells Get the Right Chromosomes

When cells divide, the chromosomes must be delivered flawlessly to the daughter cells. Missing or extra chromosomes can result in birth defects and cancer. Chance events are the starting point for chromosome delivery, which makes the process prone to error. Errors are avoided by diverse uses of mech...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1997-01, Vol.275 (5300), p.632-637
1. Verfasser:	Nicklas, R. Bruce
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell division Cellular biology Chromosomes Chromosomes - metabolism Cytogenetics Daughter cells Daughters Down Syndrome Error Correction Fundamental and applied biological sciences. Psychology Genes Genetics of eukaryotes. Biological and molecular evolution Humans Kinetochores Kinetochores - metabolism Meiosis Methods and miscellaneous Microtubules Microtubules - metabolism Mitosis Mitotic spindle apparatus Nuclear Proteins - metabolism Organic Chemistry Phosphorylation Selection, Genetic Sex chromosomes Spindle Apparatus - metabolism Stress, Mechanical X chromosome
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Beschreibung
Zusammenfassung:	When cells divide, the chromosomes must be delivered flawlessly to the daughter cells. Missing or extra chromosomes can result in birth defects and cancer. Chance events are the starting point for chromosome delivery, which makes the process prone to error. Errors are avoided by diverse uses of mechanical tension from mitotic forces. Tension stabilizes the proper chromosome configuration, controls a cell cycle checkpoint, and changes chromosome chemistry.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.275.5300.632