EFFECT OF DIPYRIDAMOLE ON BLOOD GLUCOSE AND LIVER CYCLIC AMP LEVELS AND PLATELET COUNT DURING ENDOTOXAEMIA IN MICE

SUMMARY 1. Blood glucose, liver cyclic AMP (cAMP) levels, and platelet count were studied at different times during a 12 h interval after intravenous (i.v.) endotoxin injection (40 mg/kg) in mice. 2. Blood glucose and liver cAMP levels showed a progressive decrease in endotoxic mice and the decrease...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 1988-08, Vol.15 (7), p.527-532
Hauptverfasser:	Al-Jibouri, Layla M., Najim, Rafid A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals blood glucose Blood Glucose - metabolism cyclic AMP Cyclic AMP - metabolism dipyridamole Dipyridamole - pharmacology endotoxaemia Endotoxins - pharmacology Escherichia coli - metabolism liver Liver - drug effects Liver - metabolism Male Mice Organ Size - drug effects platelet Platelet Count platelets
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Zusammenfassung:	SUMMARY 1. Blood glucose, liver cyclic AMP (cAMP) levels, and platelet count were studied at different times during a 12 h interval after intravenous (i.v.) endotoxin injection (40 mg/kg) in mice. 2. Blood glucose and liver cAMP levels showed a progressive decrease in endotoxic mice and the decrease was significant after 8 and 12 h. 3. Dipyridamole (50 mg/kg) administered intraperitoneally (i.p.) 7 h post‐endotoxin improved blood glucose and liver cAMP levels. 4. Platelet counts were decreased after 1 h in endotoxic mice and remained decreased up to 8 h. Dipyridamole administered soon after endotoxin improved platelet counts in endotoxic mice and increased survival rate to 100%.
ISSN:	0305-1870 1440-1681
DOI:	10.1111/j.1440-1681.1988.tb01110.x