In vitro activity of ciprofloxacin in combination with standard antituberculous drugs against mycobacterium tuberculosis

Chequer-board titrations show that the in vitro activity of ciprofloxacin against Mycobacterium tuberculosis is independent of that of streptomycin, isoniazid, ethambutol and pyrazinamide and confirm that there is antagonism between ciprofloxacin and rifampicin. Les tables de titrages montrent que l'activité in vitro de la ciprofloxacine vis-à-vis de Mycobacterium tuberculosis est indépendente de celle de la streptomycine, de l'isoniazide, de l'éthambutol et du pyrazinamide, et confirment l'existence d'un antagonisme entre la ciprofloxacine et la rifampicine. Las tablas de titulación muestran que la actividad in vitro de la ciprofloxacina contra Mycobacterium tuberculosis es independiente de aquélla de la estroptimicina, de la isoniacida, del etambutol y de la pirazinamida y confirman la existencia de un antagonismo entre la ciprofloxacina y la rifampicina.