Anti-inflammatory Constituents of Topically Applied Crude Drugs. III. Constituents and Anti-inflammatory Effect of Paraguayan Crude Drug “Tamandá cuná” (Catasetum barbatum LINDLE)

The 70% EtOH extract of the aerial parts of Catasetum barbatum LINDLE showed inhibitory effects on carrageenin-induced paw edema when topically applied to rats and on histamine-induced contraction in guinea pig ileum. Four compounds including a new phenanthrene, 2, 7-dihydroxy-3, 4, 8-trimethoxyphen...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1988/11/25, Vol.36(11), pp.4447-4452
Hauptverfasser:	SHIMIZU, MINEO, SHOGAWA, HISASHI, HAYASHI, TOSHIMITSU, ARISAWA, MUNEHISA, SUZUKI, SHOICHI, YOSHIZAKI, MASAO, MORITA, NAOKATA, FERRO, ESTIBAN, BASUALDO, ISABEL, BERGANZA, Luis H.
Format:	Artikel
Sprache:	eng
Schlagworte:	2, 7-dihydroxy-3, 4, 8-trimethoxyphenanthrene 2, 7-dihydroxy-3, 4-dimethoxyphenanthrene Administration, Topical Animals Anti-Inflammatory Agents - analysis anti-lammatory effect Biological and medical sciences carrageenin edema Catasetum barbatum Guinea Pigs H1-receptor In Vitro Techniques Magnetic Resonance Spectroscopy Medical sciences Muscle Contraction - drug effects Muscle, Smooth - drug effects Orchidaceae Paraguay Pharmacology. Drug treatments Plants, Medicinal - analysis
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Zusammenfassung:	The 70% EtOH extract of the aerial parts of Catasetum barbatum LINDLE showed inhibitory effects on carrageenin-induced paw edema when topically applied to rats and on histamine-induced contraction in guinea pig ileum. Four compounds including a new phenanthrene, 2, 7-dihydroxy-3, 4, 8-trimethoxyphenanthrene (2), were isolated from the active fraction. 2, 7-Dihydroxy-3, 4-dimethoxyphenanthrene (1) showed inhibitory effects in both biological assays.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.36.4447