Serology-based potency test for inactivated Newcastle disease vaccines
Twenty-seven inactivated oil-emulsion Newcastle disease vaccines were tested for potency in chickens. Serum samples from groups given 1/50 dose of vaccine were examined by the haemagglutination inhibition (HI) test and the indirect enzyme-linked immunosorbent assay (ELISA). Good correlations were ob...
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| Veröffentlicht in: | Vaccine 1988-12, Vol.6 (6), p.530-532 |
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| container_title | Vaccine |
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| creator | Goddard, R.D. Nicholas, R.A.J. Luff, P.R. |
| description | Twenty-seven inactivated oil-emulsion Newcastle disease vaccines were tested for potency in chickens. Serum samples from groups given 1/50 dose of vaccine were examined by the haemagglutination inhibition (HI) test and the indirect enzyme-linked immunosorbent assay (ELISA). Good correlations were observed between potency and HI titres and between potency and ELISA absorbance. It is recommended that a serology-based potency test replaces the challenge test, reserving challenge only for those batches of vaccines where a clear pass is not indicated. |
| doi_str_mv | 10.1016/0264-410X(88)90106-5 |
| format | Article |
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Serum samples from groups given 1/50 dose of vaccine were examined by the haemagglutination inhibition (HI) test and the indirect enzyme-linked immunosorbent assay (ELISA). Good correlations were observed between potency and HI titres and between potency and ELISA absorbance. It is recommended that a serology-based potency test replaces the challenge test, reserving challenge only for those batches of vaccines where a clear pass is not indicated.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/0264-410X(88)90106-5</identifier><identifier>PMID: 3245295</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; challenge test ; Chickens ; Dose-Response Relationship, Immunologic ; Enzyme-Linked Immunosorbent Assay ; Fundamental and applied biological sciences. Psychology ; Hemagglutination Inhibition Tests ; Immune Sera ; Microbiology ; Newcastle disease ; Newcastle Disease - prevention & control ; Newcastle disease virus ; potency test ; Vaccination ; vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, Inactivated - standards ; Viral Vaccines - standards ; Virology</subject><ispartof>Vaccine, 1988-12, Vol.6 (6), p.530-532</ispartof><rights>1988</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-3da2e0cadaa75613ce6ab21049077edb38fafd217cb5b99d11f17149c1d34a8b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0264-410X(88)90106-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6793650$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3245295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Goddard, R.D.</creatorcontrib><creatorcontrib>Nicholas, R.A.J.</creatorcontrib><creatorcontrib>Luff, P.R.</creatorcontrib><title>Serology-based potency test for inactivated Newcastle disease vaccines</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Twenty-seven inactivated oil-emulsion Newcastle disease vaccines were tested for potency in chickens. Serum samples from groups given 1/50 dose of vaccine were examined by the haemagglutination inhibition (HI) test and the indirect enzyme-linked immunosorbent assay (ELISA). Good correlations were observed between potency and HI titres and between potency and ELISA absorbance. It is recommended that a serology-based potency test replaces the challenge test, reserving challenge only for those batches of vaccines where a clear pass is not indicated.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>challenge test</subject><subject>Chickens</subject><subject>Dose-Response Relationship, Immunologic</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hemagglutination Inhibition Tests</subject><subject>Immune Sera</subject><subject>Microbiology</subject><subject>Newcastle disease</subject><subject>Newcastle Disease - prevention & control</subject><subject>Newcastle disease virus</subject><subject>potency test</subject><subject>Vaccination</subject><subject>vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Vaccines, Inactivated - standards</subject><subject>Viral Vaccines - standards</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LJDEQhoO46PjxDxT6IKKHXlOdTid9EURWXZDdgwreQnVSLZGe7jHpmWX-vRlnmKN7qsP71EvxFGMnwH8Ch-qKF1WZl8BfL7S-rDnwKpc7bAJaibyQoHfZZIvss4MY3znnUkC9x_ZEUcqilhN290Rh6Ia3Zd5gJJfNhpF6u8xGimPWDiHzPdrRL3BM4R_6ZzGOHWXOR0p8tkBrfU_xiP1osYt0vJmH7OXu1_PtQ_749_737c1jbktQYy4cFsQtOkQlKxCWKmwK4GXNlSLXCN1i6wpQtpFNXTuAFhSUtQUnStSNOGTn695ZGD7m6UYz9dFS12FPwzwapZVMvPwvCJJrCaJKYLkGbRhiDNSaWfBTDEsD3Kw8m5VEs5JotDZfns2q_3TTP2-m5LZLG7EpP9vkGC12bcDe-rjFKlWLSvKEXa8xStIWnoKJ1qcHkPOB7Gjc4L-_4xOwiJnJ</recordid><startdate>19881201</startdate><enddate>19881201</enddate><creator>Goddard, R.D.</creator><creator>Nicholas, R.A.J.</creator><creator>Luff, P.R.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19881201</creationdate><title>Serology-based potency test for inactivated Newcastle disease vaccines</title><author>Goddard, R.D. ; Nicholas, R.A.J. ; Luff, P.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-3da2e0cadaa75613ce6ab21049077edb38fafd217cb5b99d11f17149c1d34a8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>challenge test</topic><topic>Chickens</topic><topic>Dose-Response Relationship, Immunologic</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hemagglutination Inhibition Tests</topic><topic>Immune Sera</topic><topic>Microbiology</topic><topic>Newcastle disease</topic><topic>Newcastle Disease - prevention & control</topic><topic>Newcastle disease virus</topic><topic>potency test</topic><topic>Vaccination</topic><topic>vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Vaccines, Inactivated - standards</topic><topic>Viral Vaccines - standards</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goddard, R.D.</creatorcontrib><creatorcontrib>Nicholas, R.A.J.</creatorcontrib><creatorcontrib>Luff, P.R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goddard, R.D.</au><au>Nicholas, R.A.J.</au><au>Luff, P.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serology-based potency test for inactivated Newcastle disease vaccines</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>1988-12-01</date><risdate>1988</risdate><volume>6</volume><issue>6</issue><spage>530</spage><epage>532</epage><pages>530-532</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Twenty-seven inactivated oil-emulsion Newcastle disease vaccines were tested for potency in chickens. Serum samples from groups given 1/50 dose of vaccine were examined by the haemagglutination inhibition (HI) test and the indirect enzyme-linked immunosorbent assay (ELISA). Good correlations were observed between potency and HI titres and between potency and ELISA absorbance. It is recommended that a serology-based potency test replaces the challenge test, reserving challenge only for those batches of vaccines where a clear pass is not indicated.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>3245295</pmid><doi>10.1016/0264-410X(88)90106-5</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 1988-12, Vol.6 (6), p.530-532 |
| issn | 0264-410X 1873-2518 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences challenge test Chickens Dose-Response Relationship, Immunologic Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Hemagglutination Inhibition Tests Immune Sera Microbiology Newcastle disease Newcastle Disease - prevention & control Newcastle disease virus potency test Vaccination vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Inactivated - standards Viral Vaccines - standards Virology |
| title | Serology-based potency test for inactivated Newcastle disease vaccines |
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