Serology-based potency test for inactivated Newcastle disease vaccines

Twenty-seven inactivated oil-emulsion Newcastle disease vaccines were tested for potency in chickens. Serum samples from groups given 1/50 dose of vaccine were examined by the haemagglutination inhibition (HI) test and the indirect enzyme-linked immunosorbent assay (ELISA). Good correlations were ob...

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Veröffentlicht in:	Vaccine 1988-12, Vol.6 (6), p.530-532
Hauptverfasser:	Goddard, R.D., Nicholas, R.A.J., Luff, P.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences challenge test Chickens Dose-Response Relationship, Immunologic Enzyme-Linked Immunosorbent Assay Fundamental and applied biological sciences. Psychology Hemagglutination Inhibition Tests Immune Sera Microbiology Newcastle disease Newcastle Disease - prevention & control Newcastle disease virus potency test Vaccination vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Inactivated - standards Viral Vaccines - standards Virology
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Beschreibung
Zusammenfassung:	Twenty-seven inactivated oil-emulsion Newcastle disease vaccines were tested for potency in chickens. Serum samples from groups given 1/50 dose of vaccine were examined by the haemagglutination inhibition (HI) test and the indirect enzyme-linked immunosorbent assay (ELISA). Good correlations were observed between potency and HI titres and between potency and ELISA absorbance. It is recommended that a serology-based potency test replaces the challenge test, reserving challenge only for those batches of vaccines where a clear pass is not indicated.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/0264-410X(88)90106-5