Asymptomatic coronary artery disease detection: update 1996. A screening protocol using 16-lead high-resolution ECG, ultrafast CT, exercise testing, and radionuclear imaging

The authors have proposed a new four-step screening algorithm to detect asymptomatic coronary artery disease (CAD) in flight school candidates, cadets, and rated flyers of the Unites States Air Force (USAF). In step 1, the USAF Armstrong Laboratory (USAF/AL) risk profile and improved 16-lead high-resolution electrocardiogram/vectorcardiogram will be recorded at baseline. On routine follow-up evaluations, quantitative serial comparisons will be performed by the method of Kornreich. In step 2, beginning with flight school candidates and cadets, all three groups will be studied by the ultrafast computed tomograph (CT) protocol. Those candidates positive for coronary calcium will be studied by coronary angiography and ventriculography, and their eligibility for continued rated flight status will be determined by present criteria. In step 3, those candidates negative for coronary calcium by ultrafast CT will then be screened by the newly defined and improved high-sensitivity treadmill exercise test criteria. In step 4, candidates with a positive treadmill exercise test result, or who are also found in the upper quintile of the USAF/AL risk profile, wild also have exercise nuclear wall motion studies and perfusion scans. If these are abnormal and suggestive of myocardial ischemia, this subset will also be studied by heart catheterization and coronary angiography, and their eligibility for continued rated flight status will be determined by present criteria. The incidence of coronary calcium/no calcium for each degree of stenosis in the 6,000 flyers in each quintile was used to develop the following projections: (1) that more than 3 of 4 rated flyers with unsuspected CAD, and (2) more than 9 of 10 with severe flow-limiting CAD can be identified by these upgraded screening procedures. Evidence is herein presented that these enhancements will result in a major (5-8-fold) increase in case finding of this disease. Based on the estimate of four lost high-performance aircrafts per year from sudden incapacitation of the pilot due to CAD, when this four-step screen is fully operational, it can be expected to reduce the $80 million annual losses to the United States government from CAD by 85%, a savings of $68 million per year.