An investigation of the metabolism of S-carboxymethyl-L-cysteine in man using a novel HPLC-ECD method

The metabolism of an oral dose of S-carboxymethyl-L-cysteine (SCMC) in man has been studied; the quantitative determination of SCMC, S-methyl-L-cysteine (SMC) and their sulphoxide metabolites (SCMCO and SMCO), in urine, was carried out using high performance liquid chromatography (HPLC) with electro...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 1988-10, Vol.13 (4), p.253-256
Hauptverfasser:	KARIM, E. F. I. A, MILLERSHIP, J. S, TEMPLE, D. J, WOOLFSON, A. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carbocysteine - analysis Carbocysteine - metabolism Chromatography, High Pressure Liquid Cysteine - analogs & derivatives Cysteine - analysis Humans Male Medical sciences Pharmacology. Drug treatments Respiratory system Sulfoxides - analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The metabolism of an oral dose of S-carboxymethyl-L-cysteine (SCMC) in man has been studied; the quantitative determination of SCMC, S-methyl-L-cysteine (SMC) and their sulphoxide metabolites (SCMCO and SMCO), in urine, was carried out using high performance liquid chromatography (HPLC) with electrochemical detection (ECD); the possibility of stereospecific sulphoxidation was investigated.
ISSN:	0378-7966 2107-0180
DOI:	10.1007/BF03190087