Effects of dithiothreitol and ascorbate on the penetration of diclofenac across excised rat dorsal skin

The penetration of diclofenac through excised rat dorsal skin was found to be poor. Treatment of the skin with a reductant such as dithiothreitol or ascorbate increased the permeability of the skin to diclofenac, along with an increase in the protein thiol content of the stripped skin surface tissue...

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Veröffentlicht in:	Pharmaceutical research 1988-11, Vol.5 (11), p.738-740
Hauptverfasser:	NISHIBATA, T, RYTTING, J. H, TAKAHASHI, K, SAKAI, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascorbic Acid - pharmacology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Diclofenac - pharmacokinetics Dithiothreitol - pharmacology In Vitro Techniques Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Skin Absorption - drug effects
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Beschreibung
Zusammenfassung:	The penetration of diclofenac through excised rat dorsal skin was found to be poor. Treatment of the skin with a reductant such as dithiothreitol or ascorbate increased the permeability of the skin to diclofenac, along with an increase in the protein thiol content of the stripped skin surface tissue. An increase in protein thiol content may increase the hydration capability of the stratum corneum.
ISSN:	0724-8741 1573-904X
DOI:	10.1023/A:1015920230676