Potential effects of age-associated oxidative stress on mammalian oocytes/embryos
This bioessay aims to explain the different effects of maternal ageing and postovulatory oocyte ageing on mammalian oocytes/embryos under the scope of ‘the oxygen radical-mitochondrial injury hypothesis of ageing’. This hypothesis assumes a key role in the senescent process of oxygen radical damage...
Gespeichert in:
| Veröffentlicht in: | Molecular human reproduction 1996-10, Vol.2 (10), p.717-724 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 724 |
|---|---|
| container_issue | 10 |
| container_start_page | 717 |
| container_title | Molecular human reproduction |
| container_volume | 2 |
| creator | Tarin, Juan J. |
| description | This bioessay aims to explain the different effects of maternal ageing and postovulatory oocyte ageing on mammalian oocytes/embryos under the scope of ‘the oxygen radical-mitochondrial injury hypothesis of ageing’. This hypothesis assumes a key role in the senescent process of oxygen radical damage to mitochondrial DNA, proteins and lipids. It is proposed that a decrease in intracellular ATP concentrations and glutathione (GSH)/glutathione disulphide (GSSG) ratio together with a concomitant increase in cytosolic Ca2+ are major factors causing the observed detrimental effects of ageing on cytoskeletal fibres, fertilization and embryo development. |
| doi_str_mv | 10.1093/molehr/2.10.717 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78735371</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78735371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-555aa19382105fc2080b4d946d2eebf31784e99ab6430c89619a1cbf502d49383</originalsourceid><addsrcrecordid>eNo9kL1PwzAQxS0EKlCYmZAysaX1V2J7BAQFVAkqgYS6WI5zgUBSg-2i9r_HVatO9-7euzf8ELogeESwYuPedfDpxzRtI0HEATohvMQ55VgcJs2SVoqLY3QawhfGRNBCDtBAUaZKKU_Q7MVFWMTWdBk0DdgYMtdk5gNyE4KzrYlQZ27V1ia2f5CF6CGkyCLrTd-brjWLzDm7jhDG0Fd-7cIZOmpMF-B8N4fo7f7u9fYhnz5PHm-vp7nlTMS8KApjiGKSElw0lmKJK14rXtYUoGoYEZKDUqYqOcNWqpIoQ2zVFJjWPL2xIbra9v5497uEEHXfBgtdZxbglkELKVjBBEnB8TZovQvBQ6N_fNsbv9YE6w1EvYWo6eaQIKaPy131suqh3ud31JKfb_02RFjtbeO_dSmYKPTD-1yL2fTpZj6faMn-ASktfoU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78735371</pqid></control><display><type>article</type><title>Potential effects of age-associated oxidative stress on mammalian oocytes/embryos</title><source>Oxford University Press Journals</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Tarin, Juan J.</creator><creatorcontrib>Tarin, Juan J.</creatorcontrib><description>This bioessay aims to explain the different effects of maternal ageing and postovulatory oocyte ageing on mammalian oocytes/embryos under the scope of ‘the oxygen radical-mitochondrial injury hypothesis of ageing’. This hypothesis assumes a key role in the senescent process of oxygen radical damage to mitochondrial DNA, proteins and lipids. It is proposed that a decrease in intracellular ATP concentrations and glutathione (GSH)/glutathione disulphide (GSSG) ratio together with a concomitant increase in cytosolic Ca2+ are major factors causing the observed detrimental effects of ageing on cytoskeletal fibres, fertilization and embryo development.</description><identifier>ISSN: 1360-9947</identifier><identifier>EISSN: 1460-2407</identifier><identifier>DOI: 10.1093/molehr/2.10.717</identifier><identifier>PMID: 9239688</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adenosine Triphosphate - metabolism ; Adult ; ageing ; Animals ; Cellular Senescence ; Congenital Abnormalities - etiology ; Cytoskeleton - metabolism ; Cytoskeleton - ultrastructure ; DNA, Mitochondrial - metabolism ; Egg Proteins - metabolism ; embryo development ; Embryo, Mammalian - cytology ; Fertility ; Fertilization ; Fetal Proteins - metabolism ; Glutathione - metabolism ; Humans ; Mammals - embryology ; Maternal Age ; Mice ; mitochondria ; Neoplasms - etiology ; Oocytes - cytology ; Oxidation-Reduction ; Oxidative Stress ; Reactive Oxygen Species</subject><ispartof>Molecular human reproduction, 1996-10, Vol.2 (10), p.717-724</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-555aa19382105fc2080b4d946d2eebf31784e99ab6430c89619a1cbf502d49383</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9239688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tarin, Juan J.</creatorcontrib><title>Potential effects of age-associated oxidative stress on mammalian oocytes/embryos</title><title>Molecular human reproduction</title><addtitle>Mol Hum Reprod</addtitle><description>This bioessay aims to explain the different effects of maternal ageing and postovulatory oocyte ageing on mammalian oocytes/embryos under the scope of ‘the oxygen radical-mitochondrial injury hypothesis of ageing’. This hypothesis assumes a key role in the senescent process of oxygen radical damage to mitochondrial DNA, proteins and lipids. It is proposed that a decrease in intracellular ATP concentrations and glutathione (GSH)/glutathione disulphide (GSSG) ratio together with a concomitant increase in cytosolic Ca2+ are major factors causing the observed detrimental effects of ageing on cytoskeletal fibres, fertilization and embryo development.</description><subject>Adenosine Triphosphate - metabolism</subject><subject>Adult</subject><subject>ageing</subject><subject>Animals</subject><subject>Cellular Senescence</subject><subject>Congenital Abnormalities - etiology</subject><subject>Cytoskeleton - metabolism</subject><subject>Cytoskeleton - ultrastructure</subject><subject>DNA, Mitochondrial - metabolism</subject><subject>Egg Proteins - metabolism</subject><subject>embryo development</subject><subject>Embryo, Mammalian - cytology</subject><subject>Fertility</subject><subject>Fertilization</subject><subject>Fetal Proteins - metabolism</subject><subject>Glutathione - metabolism</subject><subject>Humans</subject><subject>Mammals - embryology</subject><subject>Maternal Age</subject><subject>Mice</subject><subject>mitochondria</subject><subject>Neoplasms - etiology</subject><subject>Oocytes - cytology</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Reactive Oxygen Species</subject><issn>1360-9947</issn><issn>1460-2407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL1PwzAQxS0EKlCYmZAysaX1V2J7BAQFVAkqgYS6WI5zgUBSg-2i9r_HVatO9-7euzf8ELogeESwYuPedfDpxzRtI0HEATohvMQ55VgcJs2SVoqLY3QawhfGRNBCDtBAUaZKKU_Q7MVFWMTWdBk0DdgYMtdk5gNyE4KzrYlQZ27V1ia2f5CF6CGkyCLrTd-brjWLzDm7jhDG0Fd-7cIZOmpMF-B8N4fo7f7u9fYhnz5PHm-vp7nlTMS8KApjiGKSElw0lmKJK14rXtYUoGoYEZKDUqYqOcNWqpIoQ2zVFJjWPL2xIbra9v5497uEEHXfBgtdZxbglkELKVjBBEnB8TZovQvBQ6N_fNsbv9YE6w1EvYWo6eaQIKaPy131suqh3ud31JKfb_02RFjtbeO_dSmYKPTD-1yL2fTpZj6faMn-ASktfoU</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>Tarin, Juan J.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961001</creationdate><title>Potential effects of age-associated oxidative stress on mammalian oocytes/embryos</title><author>Tarin, Juan J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-555aa19382105fc2080b4d946d2eebf31784e99ab6430c89619a1cbf502d49383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Adult</topic><topic>ageing</topic><topic>Animals</topic><topic>Cellular Senescence</topic><topic>Congenital Abnormalities - etiology</topic><topic>Cytoskeleton - metabolism</topic><topic>Cytoskeleton - ultrastructure</topic><topic>DNA, Mitochondrial - metabolism</topic><topic>Egg Proteins - metabolism</topic><topic>embryo development</topic><topic>Embryo, Mammalian - cytology</topic><topic>Fertility</topic><topic>Fertilization</topic><topic>Fetal Proteins - metabolism</topic><topic>Glutathione - metabolism</topic><topic>Humans</topic><topic>Mammals - embryology</topic><topic>Maternal Age</topic><topic>Mice</topic><topic>mitochondria</topic><topic>Neoplasms - etiology</topic><topic>Oocytes - cytology</topic><topic>Oxidation-Reduction</topic><topic>Oxidative Stress</topic><topic>Reactive Oxygen Species</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tarin, Juan J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular human reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tarin, Juan J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential effects of age-associated oxidative stress on mammalian oocytes/embryos</atitle><jtitle>Molecular human reproduction</jtitle><addtitle>Mol Hum Reprod</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>2</volume><issue>10</issue><spage>717</spage><epage>724</epage><pages>717-724</pages><issn>1360-9947</issn><eissn>1460-2407</eissn><abstract>This bioessay aims to explain the different effects of maternal ageing and postovulatory oocyte ageing on mammalian oocytes/embryos under the scope of ‘the oxygen radical-mitochondrial injury hypothesis of ageing’. This hypothesis assumes a key role in the senescent process of oxygen radical damage to mitochondrial DNA, proteins and lipids. It is proposed that a decrease in intracellular ATP concentrations and glutathione (GSH)/glutathione disulphide (GSSG) ratio together with a concomitant increase in cytosolic Ca2+ are major factors causing the observed detrimental effects of ageing on cytoskeletal fibres, fertilization and embryo development.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>9239688</pmid><doi>10.1093/molehr/2.10.717</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1360-9947 |
| ispartof | Molecular human reproduction, 1996-10, Vol.2 (10), p.717-724 |
| issn | 1360-9947 1460-2407 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78735371 |
| source | Oxford University Press Journals; MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adenosine Triphosphate - metabolism Adult ageing Animals Cellular Senescence Congenital Abnormalities - etiology Cytoskeleton - metabolism Cytoskeleton - ultrastructure DNA, Mitochondrial - metabolism Egg Proteins - metabolism embryo development Embryo, Mammalian - cytology Fertility Fertilization Fetal Proteins - metabolism Glutathione - metabolism Humans Mammals - embryology Maternal Age Mice mitochondria Neoplasms - etiology Oocytes - cytology Oxidation-Reduction Oxidative Stress Reactive Oxygen Species |
| title | Potential effects of age-associated oxidative stress on mammalian oocytes/embryos |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T05%3A02%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Potential%20effects%20of%20age-associated%20oxidative%20stress%20on%20mammalian%20oocytes/embryos&rft.jtitle=Molecular%20human%20reproduction&rft.au=Tarin,%20Juan%20J.&rft.date=1996-10-01&rft.volume=2&rft.issue=10&rft.spage=717&rft.epage=724&rft.pages=717-724&rft.issn=1360-9947&rft.eissn=1460-2407&rft_id=info:doi/10.1093/molehr/2.10.717&rft_dat=%3Cproquest_cross%3E78735371%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78735371&rft_id=info:pmid/9239688&rfr_iscdi=true |