Potential effects of age-associated oxidative stress on mammalian oocytes/embryos

This bioessay aims to explain the different effects of maternal ageing and postovulatory oocyte ageing on mammalian oocytes/embryos under the scope of ‘the oxygen radical-mitochondrial injury hypothesis of ageing’. This hypothesis assumes a key role in the senescent process of oxygen radical damage...

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Veröffentlicht in:	Molecular human reproduction 1996-10, Vol.2 (10), p.717-724
1. Verfasser:	Tarin, Juan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adult ageing Animals Cellular Senescence Congenital Abnormalities - etiology Cytoskeleton - metabolism Cytoskeleton - ultrastructure DNA, Mitochondrial - metabolism Egg Proteins - metabolism embryo development Embryo, Mammalian - cytology Fertility Fertilization Fetal Proteins - metabolism Glutathione - metabolism Humans Mammals - embryology Maternal Age Mice mitochondria Neoplasms - etiology Oocytes - cytology Oxidation-Reduction Oxidative Stress Reactive Oxygen Species
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Beschreibung
Zusammenfassung:	This bioessay aims to explain the different effects of maternal ageing and postovulatory oocyte ageing on mammalian oocytes/embryos under the scope of ‘the oxygen radical-mitochondrial injury hypothesis of ageing’. This hypothesis assumes a key role in the senescent process of oxygen radical damage to mitochondrial DNA, proteins and lipids. It is proposed that a decrease in intracellular ATP concentrations and glutathione (GSH)/glutathione disulphide (GSSG) ratio together with a concomitant increase in cytosolic Ca2+ are major factors causing the observed detrimental effects of ageing on cytoskeletal fibres, fertilization and embryo development.
ISSN:	1360-9947 1460-2407
DOI:	10.1093/molehr/2.10.717