Propionate and the production of monensins in Streptomyces cinnamonensis

Variants resistant to propionate were prepared from a mutant strain of Streptomyces cinnamonensis producing predominantly monensin A. Using selected resistants the production of monensins (in media with higher concentrations of propionate) was examined. Stimulation of monensin synthesis by propionat...

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Veröffentlicht in:	Folia microbiologica 1988-01, Vol.33 (6), p.440-446
Hauptverfasser:	MATEJU, J, KARNETOVA, J, NOHYNEK, M, VANEK, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Drug Resistance, Microbial Fundamental and applied biological sciences. Psychology Microbiology Monensin - biosynthesis monensin A monensin B monensins Mutation Propionates - pharmacology propionic acid Streptomyces - metabolism
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Beschreibung
Zusammenfassung:	Variants resistant to propionate were prepared from a mutant strain of Streptomyces cinnamonensis producing predominantly monensin A. Using selected resistants the production of monensins (in media with higher concentrations of propionate) was examined. Stimulation of monensin synthesis by propionate was observed with 70% of the resistants studied. Propionate did not influence the ratio between monensin A and B production.
ISSN:	0015-5632 1874-9356
DOI:	10.1007/BF02925768