Phenobarbital adsorption from simulated intestinal fluid U.S.P., and simulated gastric fluid, U.S.P., by two activated charcoals

Adsorption of phenobarbital from simulated intestinal and gastric fluids by two activated charcoals was studied. Adsorption isotherm data were analyzed by the linearized Langmuir equation and by nonlinear least-squares regression employing both Langmuir and Freundlich models. These analyses indicate...

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Veröffentlicht in:	Pharmaceutical research 1988-03, Vol.5 (3), p.183-186
Hauptverfasser:	WURSTER, D. E, BURKE, G. M, BERG, M. J, VENG-PEDERSEN, P, SCHOTTELIUS, D. D
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Biological and medical sciences Charcoal Gastric Juice - metabolism General pharmacology Intestinal Secretions - metabolism Medical sciences Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Phenobarbital - pharmacokinetics
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Zusammenfassung:	Adsorption of phenobarbital from simulated intestinal and gastric fluids by two activated charcoals was studied. Adsorption isotherm data were analyzed by the linearized Langmuir equation and by nonlinear least-squares regression employing both Langmuir and Freundlich models. These analyses indicated differences in the capacities of the two charcoals for phenobarbital which could not be completely explained by surface-area considerations.
ISSN:	0724-8741 1573-904X
DOI:	10.1023/A:1015969008019