Amino acids and peptides. XX: Inhibition of papain by succinyl-Gln-Val-Val-Ala-Ala-p-nitroanilide, a common sequence of endogenous thiol proteinase inhibitors

Amino acids and peptides. XX: Inhibition of papain by succinyl-Gln-Val-Val-Ala-Ala-p-nitroanilide, a common sequence of endogenous thiol proteinase inhibitors

The report deals with the synthesis of Gln-Val-Val-Ala-Gly derivatives modified at the N and/or C-terminus by the solution method, the relationship between structure and effect on thiol proteinase (papain) and an examination of the inhibitory and protective mechanisms by measuring circular dichroism...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1988-01, Vol.36 (6), p.1982-1989
Hauptverfasser: OKADA, Y, TENO, N, TSUBOI, S, NAKABAYASHI, K, ITOH, N, OKAMOTO, H, NISHI, N
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Phenomena
Chemistry
Cysteine Proteinase Inhibitors
Exact sciences and technology
Oligopeptides - chemical synthesis
Organic chemistry
papain
Papain - antagonists & inhibitors
Peptides
Preparations and properties
proteinase
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Zusammenfassung:The report deals with the synthesis of Gln-Val-Val-Ala-Gly derivatives modified at the N and/or C-terminus by the solution method, the relationship between structure and effect on thiol proteinase (papain) and an examination of the inhibitory and protective mechanisms by measuring circular dichroism (CD) spectra
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.36.1982