Growth and antigenic characteristics of basal cell carcinoma in culture

Basal cell carcinomas (BCCs) were cultured using an explant method and compared with normal cultured skin. Immunohistochemical staining revealed reduced beta 2 microglobulin uptake by BCCs in frozen section, but normal staining of the tumours in culture. In culture, fibronectin was detected on the c...

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Veröffentlicht in:	Archives of Dermatological Research 1988, Vol.280 (4), p.228-234
Hauptverfasser:	BRADBEER, M, BOURNE, A. J, AYBERK, H, TANG, S. K, MARKS, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm beta 2-Microglobulin - metabolism Biological and medical sciences Carcinoma, Basal Cell - immunology Carcinoma, Basal Cell - metabolism Carcinoma, Basal Cell - pathology Cell Division Dermatology Fibronectins - metabolism Humans Immunoenzyme Techniques Keratins - metabolism Medical sciences Skin Neoplasms - immunology Skin Neoplasms - metabolism Skin Neoplasms - pathology Tumor Cells, Cultured - immunology Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - pathology Tumors of the skin and soft tissue. Premalignant lesions
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Zusammenfassung:	Basal cell carcinomas (BCCs) were cultured using an explant method and compared with normal cultured skin. Immunohistochemical staining revealed reduced beta 2 microglobulin uptake by BCCs in frozen section, but normal staining of the tumours in culture. In culture, fibronectin was detected on the cell surface of normal keratinocytes but not on BCCs. The above differences may explain some of the behaviour of BCCs in vivo.
ISSN:	0340-3696 1432-069X
DOI:	10.1007/BF00513962