Fourier transform Raman spectroscopy of drugs: quantitative analysis of 1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sodium sulfonate: (dipyrone)

Fourier transform Raman spectroscopy of drugs: quantitative analysis of 1-phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethane sodium sulfonate: (dipyrone)

Several drugs provided by the pharmaceutical industry and containing dipyrone as the active principle have different mass percentages of the letter. We describe a procedure for the quantitative analysis of several tablets containing dipyrone (or other solid active principles). The results of Fourier...

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Veröffentlicht in:Journal of Raman spectroscopy 2003-10, Vol.34 (10), p.837-843
Hauptverfasser: Izolani, Antônio O., de Moraes, Milena T., Téllez S., Claudio A.
Format: Artikel
Sprache:eng
Schlagworte:
chemical pharmaceutical analysis
dipyrone
Drugs
Fourier transforms
FT-Raman
Pharmaceuticals
Quantitative analysis
Raman spectroscopy
Sodium
Sulfonates
Tablets
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Zusammenfassung:Several drugs provided by the pharmaceutical industry and containing dipyrone as the active principle have different mass percentages of the letter. We describe a procedure for the quantitative analysis of several tablets containing dipyrone (or other solid active principles). The results of Fourier transform Raman band analysis (band area and band height) agree well with the stated contents of dipyrone in the tablets. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:0377-0486
1097-4555
DOI:10.1002/jrs.1064