Induction of apoptosis by tomato using space mutation breeding in human colon cancer SW480 and HT-29 cells

BACKGROUND: As far as we know, there have been no reports concerning the functional characteristics of tomatoes using space mutation breeding. The aim of this study was to evaluate the anti-colon cancer effect of tomatoes M1 and M2 using space mutation breeding.RESULTS: In the present study, obvious...

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Veröffentlicht in:Journal of the science of food and agriculture 2010-03, Vol.90 (4), p.615-621
Hauptverfasser: Shi, Jiahui, Yang, Bin, Feng, Pan, Li, Duo, Zhu, Jiajin
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Sprache:eng
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Zusammenfassung:BACKGROUND: As far as we know, there have been no reports concerning the functional characteristics of tomatoes using space mutation breeding. The aim of this study was to evaluate the anti-colon cancer effect of tomatoes M1 and M2 using space mutation breeding.RESULTS: In the present study, obvious anti-cancer activity was shown with tomato juice of M1 and M2 and their parent CK treatment in colon cancer cell lines SW480 and HT-29 in cell growth inhibition. In addition, SW480 cells were more sensitive to M1 and M2 than HT-29 cells in cell apoptosis. Furthermore, M1 and M2 induced cell cycle arrest both in G0-G1 and G2/M phases.CONCLUSION: These data suggest that consumption of tomato using space mutation breeding may provide benefits to inhibit growth of colon cancer cells. Therefore, tomato production using space mutation breeding may be a good candidate for development as a dietary supplement in drug therapy for colon cancer.
ISSN:0022-5142
1097-0010
DOI:10.1002/jsfa.3858