Induction of apoptosis by tomato using space mutation breeding in human colon cancer SW480 and HT-29 cells
BACKGROUND: As far as we know, there have been no reports concerning the functional characteristics of tomatoes using space mutation breeding. The aim of this study was to evaluate the anti-colon cancer effect of tomatoes M1 and M2 using space mutation breeding.RESULTS: In the present study, obvious...
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Veröffentlicht in: | Journal of the science of food and agriculture 2010-03, Vol.90 (4), p.615-621 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | BACKGROUND: As far as we know, there have been no reports concerning the functional characteristics of tomatoes using space mutation breeding. The aim of this study was to evaluate the anti-colon cancer effect of tomatoes M1 and M2 using space mutation breeding.RESULTS: In the present study, obvious anti-cancer activity was shown with tomato juice of M1 and M2 and their parent CK treatment in colon cancer cell lines SW480 and HT-29 in cell growth inhibition. In addition, SW480 cells were more sensitive to M1 and M2 than HT-29 cells in cell apoptosis. Furthermore, M1 and M2 induced cell cycle arrest both in G0-G1 and G2/M phases.CONCLUSION: These data suggest that consumption of tomato using space mutation breeding may provide benefits to inhibit growth of colon cancer cells. Therefore, tomato production using space mutation breeding may be a good candidate for development as a dietary supplement in drug therapy for colon cancer. |
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ISSN: | 0022-5142 1097-0010 |
DOI: | 10.1002/jsfa.3858 |