Early Detection of Filaggrin-Related Atopic Dermatitis by Raman Spectroscopy and Principal Component Analysis

Early Detection of Filaggrin-Related Atopic Dermatitis by Raman Spectroscopy and Principal Component Analysis

Filaggrin (FLG) is a key protein required for the formation of the stratum corneum (SC) barrier [1], it plays an important role in the maintenance of the skin barrier function [2] and is essential for SC hydration [1]. Filaggrin gene mutations have been reported as an important predisposing factor f...

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Hauptverfasser: Ramirez-Elias, Miguel G, Gonzalez, Francisco J, Alda, Javier, Moreno-Cruz, Berenice, Martinez-Escaname, Marcela, Torres-Alvarez, Bertha, Moncada, Benjamin
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Asthma
Barriers
Dermatitis
Genes
Hydration
Maintenance
Mutations
Principal component analysis
Proteins
Raman spectroscopy
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Beschreibung
Zusammenfassung:Filaggrin (FLG) is a key protein required for the formation of the stratum corneum (SC) barrier [1], it plays an important role in the maintenance of the skin barrier function [2] and is essential for SC hydration [1]. Filaggrin gene mutations have been reported as an important predisposing factor for atopic dermatitis (AD) and secondary atopic phenotypes such as atopic asthma [3]. In this work, the presence of the protein filaggrin in the skin is detected by using Raman spectroscopy and Principal Component Analysis.
ISSN:0094-243X
DOI:10.1063/1.3482576