The Melanoma Progression-Associated Antigen P3.58 is Identical to the Intercellular Adhesion Molecule, ICAM-1

The 89kd cell surface glycoprotein, P3.58, is expressed on human malignant melanomas in situ where it is associated with an increased risk of metastatic disease. Monoclonal antibodies detecting denatured P3.58 were produced and used to isolate a P3.58 encoding eDNA clone from a human melanoma lambda...

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Veröffentlicht in:	Immunobiology (1979) 1988-12, Vol.178 (3), p.275-284
Hauptverfasser:	Johnson, Judith P., Stade, Barbara G., Hupke, Uwe, Holzmann, Bernhard, Riethmüller, Gert
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies, Monoclonal - immunology Antigenic determinants, haptens, artificial antigens Antigens Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Antigens, Surface - genetics Antigens, Surface - immunology Base Sequence Biological and medical sciences Cell Adhesion Molecules DNA - genetics DNA, Neoplasm - genetics Fundamental and applied biological sciences. Psychology Fundamental immunology Glycoproteins - genetics Glycoproteins - immunology Melanoma - genetics Melanoma - immunology Melanoma - pathology Molecular immunology Molecular Sequence Data Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Proteins - genetics Neoplasm Proteins - immunology
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Zusammenfassung:	The 89kd cell surface glycoprotein, P3.58, is expressed on human malignant melanomas in situ where it is associated with an increased risk of metastatic disease. Monoclonal antibodies detecting denatured P3.58 were produced and used to isolate a P3.58 encoding eDNA clone from a human melanoma lambda expression library. Sequencing of the cDNA revealed that the P3.58 antigen is identical to the leukocyte intercellular adhesion molecule 1 (ICAM-1).
ISSN:	0171-2985 1878-3279
DOI:	10.1016/S0171-2985(88)80071-8