Effects of 2 Years' Treatment of Osteoporosis with 1α-Hydroxy Vitamin D3 on Bone Mineral Density and Incidence of Fracture: A Placebo-Controlled, Double-Blind Prospective Study

A two-year double-blind study monitored and evaluated the effects of 1α-hydroxy vitamin D3 (1α(OH)D3) on the lumbar (L2-4BMD) and total body bone mineral densities (TBBMD) and occurrence of fracture in 113 female osteoporotic patients receiving 0.75μg/day of 1α(OH)D3 (n=57) or a placebo (n=56) with...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Endocrine Journal 1996, Vol.43(2), pp.211-220
Hauptverfasser:	SHIRAKI, MASATAKA, KUSHIDA, KAZUHIRO, YAMAZAKI, KAORU, NAGAI, TSUNEJI, INOUE, TETSUO, ORIMO, HAJIME
Format:	Artikel
Sprache:	eng
Schlagworte:	1α-Hydroxy vitamin D3 Alkaline Phosphatase - blood Bone and Bones - injuries Bone Density Bone mineral density Calcium - blood Calcium - urine Double-Blind Method Female Fractures, Bone - prevention & control Humans Hydroxycholecalciferols - therapeutic use Incidence of fracture Lumbar Vertebrae - injuries Middle Aged Osteoporosis Osteoporosis - drug therapy Parathyroid Hormone - blood Placebos Prospective Studies Space life sciences Two years' treatment
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A two-year double-blind study monitored and evaluated the effects of 1α-hydroxy vitamin D3 (1α(OH)D3) on the lumbar (L2-4BMD) and total body bone mineral densities (TBBMD) and occurrence of fracture in 113 female osteoporotic patients receiving 0.75μg/day of 1α(OH)D3 (n=57) or a placebo (n=56) with calcium supplementation in both groups. L2-4BMD increased 1.81% and 2.32% after one and 2 years in the 1α(OH)D3 group, but decreased 1.89% (P
ISSN:	0918-8959 1348-4540
DOI:	10.1507/endocrj.43.211