6-APA Production in a Pilot Plant with an Immobilized Pen V Acylase (SEMACYLASE®)

6-APA Production in a Pilot Plant with an Immobilized Pen V Acylase (SEMACYLASE®)

The industrial production of semisynthetic penicillins is based upon the use of 6-aminopenicillanic acid (6-APA), which is produced from one of the fermented penicillins--penicillin V or G. In this report, we describe two possible setups for the use of an immobilized pen V acylase from Novo Industri...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Annals of the New York Academy of Sciences 1988, Vol.542 (1), p.360-365
Hauptverfasser: MØLLGAARD, HENRIK, KARLSEN, LARS GULDBAEK
Format: Artikel
Sprache:eng
Schlagworte:
6-aminopenicillanic acid
Amidohydrolases - metabolism
Biomedical Engineering
bioreactors
Enzymes, Immobilized - metabolism
Kinetics
Penicillanic Acid - chemical synthesis
penicillin amidase
Penicillin Amidase - metabolism
penicillin V acylase
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 365
container_issue 1
container_start_page 360
container_title Annals of the New York Academy of Sciences
container_volume 542
creator MØLLGAARD, HENRIK
KARLSEN, LARS GULDBAEK
description The industrial production of semisynthetic penicillins is based upon the use of 6-aminopenicillanic acid (6-APA), which is produced from one of the fermented penicillins--penicillin V or G. In this report, we describe two possible setups for the use of an immobilized pen V acylase from Novo Industri A/S (SEMACYLASE super(TM)) on a pilot-plant scale. The basic properties of SEMACYLASE super(TM) have been described previously.
doi_str_mv 10.1111/j.1749-6632.1988.tb25858.x
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78684150</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78684150</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2970-f8558f2119f4d263cf2ac1985fa02da0cfc0c4e505c88b813ae66437dfcddb643</originalsourceid><addsrcrecordid>eNqVkN9O2zAUxi0Ego7xCJOsXSB2kWA78Z_sBoWuMKSORSusghvLcWzNJX9YnIqWh9pD7MlI1Kq3086Nj_R95zs-PwA-YhTivs4XIeZxEjAWkRAnQoRdTqigIlztgdFO2gcjhDgPREKiI_DO-wVCmIiYH4JDIiiJuRiBHyxIsxRmbVMsdeeaGroaKpi5sulgVqq6gy-u-wVVDW-qqsld6V5NATNTw58w1etSeQPPZpNv6fhhms4mf_98eg8OrCq9Odm-x-D-anI3_hpMv1_fjNNpoEnCUWAFpcISjBMbF4RF2hKl-2uoVYgUCmmrkY4NRVQLkQscKcNYHPHC6qLI--4YnG5yn9vm99L4TlbOa1P2nzbN0ksumIgxRf80YioGaKQ3ft4Yddt43xorn1tXqXYtMZIDebmQg1MOeOVAXm7Jy1U__GG7ZZlXptiNblH3-sVGf3GlWf9Hsrx9SGcRG-4INgnOd2a1S1Dtk2Q84lTOb6_l_OoLfZyTRF5Gb5avoQU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15817492</pqid></control><display><type>article</type><title>6-APA Production in a Pilot Plant with an Immobilized Pen V Acylase (SEMACYLASE®)</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>MØLLGAARD, HENRIK ; KARLSEN, LARS GULDBAEK</creator><creatorcontrib>MØLLGAARD, HENRIK ; KARLSEN, LARS GULDBAEK</creatorcontrib><description>The industrial production of semisynthetic penicillins is based upon the use of 6-aminopenicillanic acid (6-APA), which is produced from one of the fermented penicillins--penicillin V or G. In this report, we describe two possible setups for the use of an immobilized pen V acylase from Novo Industri A/S (SEMACYLASE super(TM)) on a pilot-plant scale. The basic properties of SEMACYLASE super(TM) have been described previously.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1111/j.1749-6632.1988.tb25858.x</identifier><identifier>PMID: 2852478</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>6-aminopenicillanic acid ; Amidohydrolases - metabolism ; Biomedical Engineering ; bioreactors ; Enzymes, Immobilized - metabolism ; Kinetics ; Penicillanic Acid - chemical synthesis ; penicillin amidase ; Penicillin Amidase - metabolism ; penicillin V acylase</subject><ispartof>Annals of the New York Academy of Sciences, 1988, Vol.542 (1), p.360-365</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1749-6632.1988.tb25858.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1749-6632.1988.tb25858.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2852478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MØLLGAARD, HENRIK</creatorcontrib><creatorcontrib>KARLSEN, LARS GULDBAEK</creatorcontrib><title>6-APA Production in a Pilot Plant with an Immobilized Pen V Acylase (SEMACYLASE®)</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>The industrial production of semisynthetic penicillins is based upon the use of 6-aminopenicillanic acid (6-APA), which is produced from one of the fermented penicillins--penicillin V or G. In this report, we describe two possible setups for the use of an immobilized pen V acylase from Novo Industri A/S (SEMACYLASE super(TM)) on a pilot-plant scale. The basic properties of SEMACYLASE super(TM) have been described previously.</description><subject>6-aminopenicillanic acid</subject><subject>Amidohydrolases - metabolism</subject><subject>Biomedical Engineering</subject><subject>bioreactors</subject><subject>Enzymes, Immobilized - metabolism</subject><subject>Kinetics</subject><subject>Penicillanic Acid - chemical synthesis</subject><subject>penicillin amidase</subject><subject>Penicillin Amidase - metabolism</subject><subject>penicillin V acylase</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkN9O2zAUxi0Ego7xCJOsXSB2kWA78Z_sBoWuMKSORSusghvLcWzNJX9YnIqWh9pD7MlI1Kq3086Nj_R95zs-PwA-YhTivs4XIeZxEjAWkRAnQoRdTqigIlztgdFO2gcjhDgPREKiI_DO-wVCmIiYH4JDIiiJuRiBHyxIsxRmbVMsdeeaGroaKpi5sulgVqq6gy-u-wVVDW-qqsld6V5NATNTw58w1etSeQPPZpNv6fhhms4mf_98eg8OrCq9Odm-x-D-anI3_hpMv1_fjNNpoEnCUWAFpcISjBMbF4RF2hKl-2uoVYgUCmmrkY4NRVQLkQscKcNYHPHC6qLI--4YnG5yn9vm99L4TlbOa1P2nzbN0ksumIgxRf80YioGaKQ3ft4Yddt43xorn1tXqXYtMZIDebmQg1MOeOVAXm7Jy1U__GG7ZZlXptiNblH3-sVGf3GlWf9Hsrx9SGcRG-4INgnOd2a1S1Dtk2Q84lTOb6_l_OoLfZyTRF5Gb5avoQU</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>MØLLGAARD, HENRIK</creator><creator>KARLSEN, LARS GULDBAEK</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>6-APA Production in a Pilot Plant with an Immobilized Pen V Acylase (SEMACYLASE®)</title><author>MØLLGAARD, HENRIK ; KARLSEN, LARS GULDBAEK</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2970-f8558f2119f4d263cf2ac1985fa02da0cfc0c4e505c88b813ae66437dfcddb643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>6-aminopenicillanic acid</topic><topic>Amidohydrolases - metabolism</topic><topic>Biomedical Engineering</topic><topic>bioreactors</topic><topic>Enzymes, Immobilized - metabolism</topic><topic>Kinetics</topic><topic>Penicillanic Acid - chemical synthesis</topic><topic>penicillin amidase</topic><topic>Penicillin Amidase - metabolism</topic><topic>penicillin V acylase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MØLLGAARD, HENRIK</creatorcontrib><creatorcontrib>KARLSEN, LARS GULDBAEK</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MØLLGAARD, HENRIK</au><au>KARLSEN, LARS GULDBAEK</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>6-APA Production in a Pilot Plant with an Immobilized Pen V Acylase (SEMACYLASE®)</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>1988</date><risdate>1988</risdate><volume>542</volume><issue>1</issue><spage>360</spage><epage>365</epage><pages>360-365</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>The industrial production of semisynthetic penicillins is based upon the use of 6-aminopenicillanic acid (6-APA), which is produced from one of the fermented penicillins--penicillin V or G. In this report, we describe two possible setups for the use of an immobilized pen V acylase from Novo Industri A/S (SEMACYLASE super(TM)) on a pilot-plant scale. The basic properties of SEMACYLASE super(TM) have been described previously.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2852478</pmid><doi>10.1111/j.1749-6632.1988.tb25858.x</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0077-8923
ispartof Annals of the New York Academy of Sciences, 1988, Vol.542 (1), p.360-365
issn 0077-8923
1749-6632
language eng
recordid cdi_proquest_miscellaneous_78684150
source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects 6-aminopenicillanic acid
Amidohydrolases - metabolism
Biomedical Engineering
bioreactors
Enzymes, Immobilized - metabolism
Kinetics
Penicillanic Acid - chemical synthesis
penicillin amidase
Penicillin Amidase - metabolism
penicillin V acylase
title 6-APA Production in a Pilot Plant with an Immobilized Pen V Acylase (SEMACYLASE®)
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T04%3A52%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=6-APA%20Production%20in%20a%20Pilot%20Plant%20with%20an%20Immobilized%20Pen%20V%20Acylase%20(SEMACYLASE%C2%AE)&rft.jtitle=Annals%20of%20the%20New%20York%20Academy%20of%20Sciences&rft.au=M%C3%98LLGAARD,%20HENRIK&rft.date=1988&rft.volume=542&rft.issue=1&rft.spage=360&rft.epage=365&rft.pages=360-365&rft.issn=0077-8923&rft.eissn=1749-6632&rft_id=info:doi/10.1111/j.1749-6632.1988.tb25858.x&rft_dat=%3Cproquest_cross%3E78684150%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15817492&rft_id=info:pmid/2852478&rfr_iscdi=true