Grooming behavior induced by substance P

Grooming behavior induced by substance P

The intracerebroventricular (i.c.v.) administration of substance P elicits in rats an excessive grooming that is characterized by body grooming, anogenital grooming and scratching. The total grooming scores displayed by rats treated with substance P hardly exceeded 23% of the theoretical maximal gro...

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Veröffentlicht in:European journal of pharmacology 1988-09, Vol.154 (2), p.217-220
Hauptverfasser: Van Wimersma Greidanus, Tjeerd B., Maigret, Carla
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological and medical sciences
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Grooming - drug effects
Grooming behavior
Haloperidol
Haloperidol - pharmacology
Hormones and neuropeptides. Regulation
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Injections, Intraventricular
Male
Naloxone
Naloxone - pharmacology
Neurotensin
Neurotensin - pharmacology
Rats
Rats, Inbred Strains
Substance P
Substance P - pharmacology
Vertebrates: endocrinology
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Zusammenfassung:The intracerebroventricular (i.c.v.) administration of substance P elicits in rats an excessive grooming that is characterized by body grooming, anogenital grooming and scratching. The total grooming scores displayed by rats treated with substance P hardly exceeded 23% of the theoretical maximal grooming score. Substance P-induced excessive grooming was suppressed by pretreatment with naloxone, haloperidol on neurotensin. It is concluded that substance P induces excessive grooming with a pattern different from that of grooming elicited by other peptides.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(88)90102-1