Histones interact with immunoglobulins and give them polyspecificity

The presence of antihistone antibodies was determined in different commerical immunoglobulin preparations. The ability of histones to perform the function of cofactor in interaction of immunoglobulin preparations and sera of healthy people with charged molecules such as DNA, cardiolipin and phosphatidylcholine, was determined. The addition of histones to immunoglobulin preparations or serum samples is accompanied by forming the stable complex, components of which interact with the charged molecules. The capacity of histones to play the role of cofactor is less evident in the case when they are preincubated with DNA or cardiolipin. The interaction of natural antibodies with histones can explain their polyspecificity in some cases.