Intravenous albumin prevents moderate—severe ovarian hyperstimulation in in-vitro fertilization patients: a prospective, randomized and controlled study

Objective: To assess the effectiveness of intravenous administration of albumin in prevention of ovarian hyperstimulation syndrome (OHSS) in patients of an in-vitro fertilization program. Study Design: Prospective randomized study. Patients with hCG day E2 levels are 11 010 pmol/1 (3000 pg/ml) or more were recruited into two groups. Group A ( n = 27) received 10 g 20%. 50 ml human albumin infusion before oocyte pick-up and no medication was administered in Group B ( n = 28). Results: Patients were similar in terms of cycle characteristics. No moderate-severe OHSS developed in Group A whereas one severe OHSS case and four moderate OHSS cases developed in Group B. Statistical analysis revealed a significant ( P < 0.05) protection in albumin treated group. Conclusion: Human albumin proves effectiveness in prevention of moderate-severe OHSS