Influence of 3,5,3'-triiodo-L-thyronine on the hepatic enzyme activities responsible for the metabolism of xenobiotics during the development of the chick embryo
The influence of thyroid hormones on microsomal drug metabolizing enzymes was studied in hypothyroid newborn rats and chick embryos. Administration of 3,5,3'-triiodo-L-thyronine strongly decreased the microsomal cytochrome P 450 content in hypothyroid new-born rats and thus could render the rat...
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| Veröffentlicht in: | Comptes rendus des seances de la Societe de biologie et de ses filiales 1988, Vol.182 (3), p.316-323 |
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| container_title | Comptes rendus des seances de la Societe de biologie et de ses filiales |
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| creator | Goudonnet, H Mounié, J Escousse, A Truchot, R C |
| description | The influence of thyroid hormones on microsomal drug metabolizing enzymes was studied in hypothyroid newborn rats and chick embryos. Administration of 3,5,3'-triiodo-L-thyronine strongly decreased the microsomal cytochrome P 450 content in hypothyroid new-born rats and thus could render the rat pup more susceptible to hepatotoxicity from drugs. The drug metabolizing system in 20 days old chick embryos was less sensitive to the effects of thyroid hormone, but administration of phenobarbital was accompanied by a strongly induction effect on microsomal enzyme activities. |
| format | Article |
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Administration of 3,5,3'-triiodo-L-thyronine strongly decreased the microsomal cytochrome P 450 content in hypothyroid new-born rats and thus could render the rat pup more susceptible to hepatotoxicity from drugs. 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Administration of 3,5,3'-triiodo-L-thyronine strongly decreased the microsomal cytochrome P 450 content in hypothyroid new-born rats and thus could render the rat pup more susceptible to hepatotoxicity from drugs. The drug metabolizing system in 20 days old chick embryos was less sensitive to the effects of thyroid hormone, but administration of phenobarbital was accompanied by a strongly induction effect on microsomal enzyme activities.</description><subject>7-Alkoxycoumarin O-Dealkylase</subject><subject>Animals</subject><subject>Chick Embryo</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Female</subject><subject>Hypothyroidism - enzymology</subject><subject>Hypothyroidism - metabolism</subject><subject>Microsomes, Liver - enzymology</subject><subject>Microsomes, Liver - metabolism</subject><subject>Oxygenases - metabolism</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Triiodothyronine - pharmacology</subject><subject>Xenobiotics - metabolism</subject><issn>0037-9026</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNot0M1OwzAMB_AeQGOCPQJSTnBZpbRpk-aIJj4mTeKye5WkDo1okpKkE-VteFO2sZMl--e_JV9lS4wJyzku6U22itFIjHFRcIzrRbYoOaMl58vsd-v0MIFTgLxGZF2vyWOegjG-8_kuT_0cvDPuOHUo9YB6GEUyCoH7mS0goZI5mGQgogBx9O54ZwCkfThrC0lIP5hoT-nf4Lw0_rgeUTcF4z7OqIMDDH604NJJnVqqN-oTgZVh9nfZtRZDhNWl3mb7l-f95i3fvb9uN0-7fKwJzxUvCt2IGgNVmlMuBBO8ZKwppayqjlWqIJR0Wte6qRpBBaGMEVpLxXUnJSe32cN_7Bj81wQxtdZEBcMgHPgptqyhjBaEHeH9BU7SQteOwVgR5vbyUvIHhuB1oQ</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Goudonnet, H</creator><creator>Mounié, J</creator><creator>Escousse, A</creator><creator>Truchot, R C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Influence of 3,5,3'-triiodo-L-thyronine on the hepatic enzyme activities responsible for the metabolism of xenobiotics during the development of the chick embryo</title><author>Goudonnet, H ; Mounié, J ; Escousse, A ; Truchot, R C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p539-c911f8a50e6cf969aa7a927782bb44d74c1363dff5f848a6a3677365bc9fdbb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>1988</creationdate><topic>7-Alkoxycoumarin O-Dealkylase</topic><topic>Animals</topic><topic>Chick Embryo</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>Female</topic><topic>Hypothyroidism - enzymology</topic><topic>Hypothyroidism - metabolism</topic><topic>Microsomes, Liver - enzymology</topic><topic>Microsomes, Liver - metabolism</topic><topic>Oxygenases - metabolism</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Triiodothyronine - pharmacology</topic><topic>Xenobiotics - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Goudonnet, H</creatorcontrib><creatorcontrib>Mounié, J</creatorcontrib><creatorcontrib>Escousse, A</creatorcontrib><creatorcontrib>Truchot, R C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Comptes rendus des seances de la Societe de biologie et de ses filiales</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goudonnet, H</au><au>Mounié, J</au><au>Escousse, A</au><au>Truchot, R C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of 3,5,3'-triiodo-L-thyronine on the hepatic enzyme activities responsible for the metabolism of xenobiotics during the development of the chick embryo</atitle><jtitle>Comptes rendus des seances de la Societe de biologie et de ses filiales</jtitle><addtitle>C R Seances Soc Biol Fil</addtitle><date>1988</date><risdate>1988</risdate><volume>182</volume><issue>3</issue><spage>316</spage><epage>323</epage><pages>316-323</pages><issn>0037-9026</issn><abstract>The influence of thyroid hormones on microsomal drug metabolizing enzymes was studied in hypothyroid newborn rats and chick embryos. 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| ispartof | Comptes rendus des seances de la Societe de biologie et de ses filiales, 1988, Vol.182 (3), p.316-323 |
| issn | 0037-9026 |
| language | fre |
| recordid | cdi_proquest_miscellaneous_78676137 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Gallica Periodicals |
| subjects | 7-Alkoxycoumarin O-Dealkylase Animals Chick Embryo Cytochrome P-450 Enzyme System - metabolism Female Hypothyroidism - enzymology Hypothyroidism - metabolism Microsomes, Liver - enzymology Microsomes, Liver - metabolism Oxygenases - metabolism Pregnancy Rats Rats, Inbred Strains Triiodothyronine - pharmacology Xenobiotics - metabolism |
| title | Influence of 3,5,3'-triiodo-L-thyronine on the hepatic enzyme activities responsible for the metabolism of xenobiotics during the development of the chick embryo |
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