Influence of 3,5,3'-triiodo-L-thyronine on the hepatic enzyme activities responsible for the metabolism of xenobiotics during the development of the chick embryo

Influence of 3,5,3'-triiodo-L-thyronine on the hepatic enzyme activities responsible for the metabolism of xenobiotics during the development of the chick embryo

The influence of thyroid hormones on microsomal drug metabolizing enzymes was studied in hypothyroid newborn rats and chick embryos. Administration of 3,5,3'-triiodo-L-thyronine strongly decreased the microsomal cytochrome P 450 content in hypothyroid new-born rats and thus could render the rat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Comptes rendus des seances de la Societe de biologie et de ses filiales 1988, Vol.182 (3), p.316-323
Hauptverfasser: Goudonnet, H, Mounié, J, Escousse, A, Truchot, R C
Format: Artikel
Sprache:fre
Schlagworte:
7-Alkoxycoumarin O-Dealkylase
Animals
Chick Embryo
Cytochrome P-450 Enzyme System - metabolism
Female
Hypothyroidism - enzymology
Hypothyroidism - metabolism
Microsomes, Liver - enzymology
Microsomes, Liver - metabolism
Oxygenases - metabolism
Pregnancy
Rats
Rats, Inbred Strains
Triiodothyronine - pharmacology
Xenobiotics - metabolism
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The influence of thyroid hormones on microsomal drug metabolizing enzymes was studied in hypothyroid newborn rats and chick embryos. Administration of 3,5,3'-triiodo-L-thyronine strongly decreased the microsomal cytochrome P 450 content in hypothyroid new-born rats and thus could render the rat pup more susceptible to hepatotoxicity from drugs. The drug metabolizing system in 20 days old chick embryos was less sensitive to the effects of thyroid hormone, but administration of phenobarbital was accompanied by a strongly induction effect on microsomal enzyme activities.
ISSN:0037-9026