Evaluation of samarium-153 and holmium-166-EDTMP in the normal baboon model
Bone-seeking radiopharmaceuticals such as ethylenediaminetetramethylene phosphonate (EDTMP) complexes of samarium-153 and holmium-166 are receiving considerable attention for therapeutic treatment of bone metastases. In this study, using the baboon experimental model, multicompartmental analysis rev...
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| Veröffentlicht in: | Nuclear medicine and biology 1996-11, Vol.23 (8), p.935-940 |
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| creator | Louw, W.K.A. Dormehl, I.C. van Rensburg, A.J. Hugo, N. Alberts, A.S. Forsyth, O.E. Beverley, G. Sweetlove, M.A. Marais, J. Lötter, M.G. van Aswegen, A. |
| description | Bone-seeking radiopharmaceuticals such as ethylenediaminetetramethylene phosphonate (EDTMP) complexes of samarium-153 and holmium-166 are receiving considerable attention for therapeutic treatment of bone metastases. In this study, using the baboon experimental model, multicompartmental analysis revealed that with regard to pharmacokinetics, biodistribution, and skeletal localisation,
166Ho-EDTMP was significantly inferior to
153Sm-EDTMP and
99mTc-MDP. A more suitable
166Ho-bone-seeking agent should thus be sought for closer similarity to
153Sm-EDTMP to exploit fully the therapeutic potential of its shorter half-life and more energetic beta radiation. |
| doi_str_mv | 10.1016/S0969-8051(96)00117-5 |
| format | Article |
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166Ho-EDTMP was significantly inferior to
153Sm-EDTMP and
99mTc-MDP. A more suitable
166Ho-bone-seeking agent should thus be sought for closer similarity to
153Sm-EDTMP to exploit fully the therapeutic potential of its shorter half-life and more energetic beta radiation.</description><identifier>ISSN: 0969-8051</identifier><identifier>EISSN: 1872-9614</identifier><identifier>DOI: 10.1016/S0969-8051(96)00117-5</identifier><identifier>PMID: 9004281</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Absorption ; Animals ; Baboon model ; Biological and medical sciences ; Body Fluid Compartments ; Bone and Bones - metabolism ; Diseases of the osteoarticular system ; EDTMP ; Evaluation Studies as Topic ; Half-Life ; Holmium - pharmacokinetics ; Holmium-166 ; Male ; Medical sciences ; Organometallic Compounds - pharmacokinetics ; Organophosphorus Compounds - pharmacokinetics ; Papio ; Pharmacokinetics ; Radioisotopes - pharmacokinetics ; Radiopharmaceuticals - pharmacokinetics ; Samarium - pharmacokinetics ; Samarium-153 ; Tissue Distribution ; Tumors of striated muscle and skeleton</subject><ispartof>Nuclear medicine and biology, 1996-11, Vol.23 (8), p.935-940</ispartof><rights>1996</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-64aa0b42477b03babb8e881d0e955d5d06acdc51b08b5fbf46aac8a3dd03b9273</citedby><cites>FETCH-LOGICAL-c420t-64aa0b42477b03babb8e881d0e955d5d06acdc51b08b5fbf46aac8a3dd03b9273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0969805196001175$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2524753$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9004281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Louw, W.K.A.</creatorcontrib><creatorcontrib>Dormehl, I.C.</creatorcontrib><creatorcontrib>van Rensburg, A.J.</creatorcontrib><creatorcontrib>Hugo, N.</creatorcontrib><creatorcontrib>Alberts, A.S.</creatorcontrib><creatorcontrib>Forsyth, O.E.</creatorcontrib><creatorcontrib>Beverley, G.</creatorcontrib><creatorcontrib>Sweetlove, M.A.</creatorcontrib><creatorcontrib>Marais, J.</creatorcontrib><creatorcontrib>Lötter, M.G.</creatorcontrib><creatorcontrib>van Aswegen, A.</creatorcontrib><title>Evaluation of samarium-153 and holmium-166-EDTMP in the normal baboon model</title><title>Nuclear medicine and biology</title><addtitle>Nucl Med Biol</addtitle><description>Bone-seeking radiopharmaceuticals such as ethylenediaminetetramethylene phosphonate (EDTMP) complexes of samarium-153 and holmium-166 are receiving considerable attention for therapeutic treatment of bone metastases. In this study, using the baboon experimental model, multicompartmental analysis revealed that with regard to pharmacokinetics, biodistribution, and skeletal localisation,
166Ho-EDTMP was significantly inferior to
153Sm-EDTMP and
99mTc-MDP. A more suitable
166Ho-bone-seeking agent should thus be sought for closer similarity to
153Sm-EDTMP to exploit fully the therapeutic potential of its shorter half-life and more energetic beta radiation.</description><subject>Absorption</subject><subject>Animals</subject><subject>Baboon model</subject><subject>Biological and medical sciences</subject><subject>Body Fluid Compartments</subject><subject>Bone and Bones - metabolism</subject><subject>Diseases of the osteoarticular system</subject><subject>EDTMP</subject><subject>Evaluation Studies as Topic</subject><subject>Half-Life</subject><subject>Holmium - pharmacokinetics</subject><subject>Holmium-166</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organometallic Compounds - pharmacokinetics</subject><subject>Organophosphorus Compounds - pharmacokinetics</subject><subject>Papio</subject><subject>Pharmacokinetics</subject><subject>Radioisotopes - pharmacokinetics</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><subject>Samarium - pharmacokinetics</subject><subject>Samarium-153</subject><subject>Tissue Distribution</subject><subject>Tumors of striated muscle and skeleton</subject><issn>0969-8051</issn><issn>1872-9614</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi0Egi3tT0DKoULtIeBJbMc-VRUstCqolUrP1vgjwlUSUztB6r_H7K72ymk0muedGT2EnAG9AAri8jdVQtWScvikxGdKAbqaH5AVyK6plQB2SFZ75IS8y_lvgQQDekyOFaWskbAiP9bPOCw4hzhVsa8yjpjCMtbA2wonVz3GYdz0QtTr64f7X1WYqvnRV1NMIw6VQRNLdIzOD-_JUY9D9h929ZT8uVk_XH2r737efr_6eldb1tC5FgyRGtawrjO0LQuM9FKCo15x7rijAq2zHAyVhvemZwLRSmydK7RquvaUnG_3PqX4b_F51mPI1g8DTj4uWXdSdK0E9SYIXAKwrikg34I2xZyT7_VTCsXEfw1Uv9rWG9v6VaVWQm9sa15yZ7sDixm926d2esv8426O2eLQJ5xsyHus4UUCbwv2ZYv5Yu05-KSzDX6y3oXk7axdDG888gJ-mZmr</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Louw, W.K.A.</creator><creator>Dormehl, I.C.</creator><creator>van Rensburg, A.J.</creator><creator>Hugo, N.</creator><creator>Alberts, A.S.</creator><creator>Forsyth, O.E.</creator><creator>Beverley, G.</creator><creator>Sweetlove, M.A.</creator><creator>Marais, J.</creator><creator>Lötter, M.G.</creator><creator>van Aswegen, A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Evaluation of samarium-153 and holmium-166-EDTMP in the normal baboon model</title><author>Louw, W.K.A. ; Dormehl, I.C. ; van Rensburg, A.J. ; Hugo, N. ; Alberts, A.S. ; Forsyth, O.E. ; Beverley, G. ; Sweetlove, M.A. ; Marais, J. ; Lötter, M.G. ; van Aswegen, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-64aa0b42477b03babb8e881d0e955d5d06acdc51b08b5fbf46aac8a3dd03b9273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Absorption</topic><topic>Animals</topic><topic>Baboon model</topic><topic>Biological and medical sciences</topic><topic>Body Fluid Compartments</topic><topic>Bone and Bones - metabolism</topic><topic>Diseases of the osteoarticular system</topic><topic>EDTMP</topic><topic>Evaluation Studies as Topic</topic><topic>Half-Life</topic><topic>Holmium - pharmacokinetics</topic><topic>Holmium-166</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organometallic Compounds - pharmacokinetics</topic><topic>Organophosphorus Compounds - pharmacokinetics</topic><topic>Papio</topic><topic>Pharmacokinetics</topic><topic>Radioisotopes - pharmacokinetics</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><topic>Samarium - pharmacokinetics</topic><topic>Samarium-153</topic><topic>Tissue Distribution</topic><topic>Tumors of striated muscle and skeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Louw, W.K.A.</creatorcontrib><creatorcontrib>Dormehl, I.C.</creatorcontrib><creatorcontrib>van Rensburg, A.J.</creatorcontrib><creatorcontrib>Hugo, N.</creatorcontrib><creatorcontrib>Alberts, A.S.</creatorcontrib><creatorcontrib>Forsyth, O.E.</creatorcontrib><creatorcontrib>Beverley, G.</creatorcontrib><creatorcontrib>Sweetlove, M.A.</creatorcontrib><creatorcontrib>Marais, J.</creatorcontrib><creatorcontrib>Lötter, M.G.</creatorcontrib><creatorcontrib>van Aswegen, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine and biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Louw, W.K.A.</au><au>Dormehl, I.C.</au><au>van Rensburg, A.J.</au><au>Hugo, N.</au><au>Alberts, A.S.</au><au>Forsyth, O.E.</au><au>Beverley, G.</au><au>Sweetlove, M.A.</au><au>Marais, J.</au><au>Lötter, M.G.</au><au>van Aswegen, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of samarium-153 and holmium-166-EDTMP in the normal baboon model</atitle><jtitle>Nuclear medicine and biology</jtitle><addtitle>Nucl Med Biol</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>23</volume><issue>8</issue><spage>935</spage><epage>940</epage><pages>935-940</pages><issn>0969-8051</issn><eissn>1872-9614</eissn><abstract>Bone-seeking radiopharmaceuticals such as ethylenediaminetetramethylene phosphonate (EDTMP) complexes of samarium-153 and holmium-166 are receiving considerable attention for therapeutic treatment of bone metastases. In this study, using the baboon experimental model, multicompartmental analysis revealed that with regard to pharmacokinetics, biodistribution, and skeletal localisation,
166Ho-EDTMP was significantly inferior to
153Sm-EDTMP and
99mTc-MDP. A more suitable
166Ho-bone-seeking agent should thus be sought for closer similarity to
153Sm-EDTMP to exploit fully the therapeutic potential of its shorter half-life and more energetic beta radiation.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>9004281</pmid><doi>10.1016/S0969-8051(96)00117-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0969-8051 |
| ispartof | Nuclear medicine and biology, 1996-11, Vol.23 (8), p.935-940 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Absorption Animals Baboon model Biological and medical sciences Body Fluid Compartments Bone and Bones - metabolism Diseases of the osteoarticular system EDTMP Evaluation Studies as Topic Half-Life Holmium - pharmacokinetics Holmium-166 Male Medical sciences Organometallic Compounds - pharmacokinetics Organophosphorus Compounds - pharmacokinetics Papio Pharmacokinetics Radioisotopes - pharmacokinetics Radiopharmaceuticals - pharmacokinetics Samarium - pharmacokinetics Samarium-153 Tissue Distribution Tumors of striated muscle and skeleton |
| title | Evaluation of samarium-153 and holmium-166-EDTMP in the normal baboon model |
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