Evaluation of samarium-153 and holmium-166-EDTMP in the normal baboon model

Bone-seeking radiopharmaceuticals such as ethylenediaminetetramethylene phosphonate (EDTMP) complexes of samarium-153 and holmium-166 are receiving considerable attention for therapeutic treatment of bone metastases. In this study, using the baboon experimental model, multicompartmental analysis rev...

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Veröffentlicht in:	Nuclear medicine and biology 1996-11, Vol.23 (8), p.935-940
Hauptverfasser:	Louw, W.K.A., Dormehl, I.C., van Rensburg, A.J., Hugo, N., Alberts, A.S., Forsyth, O.E., Beverley, G., Sweetlove, M.A., Marais, J., Lötter, M.G., van Aswegen, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Animals Baboon model Biological and medical sciences Body Fluid Compartments Bone and Bones - metabolism Diseases of the osteoarticular system EDTMP Evaluation Studies as Topic Half-Life Holmium - pharmacokinetics Holmium-166 Male Medical sciences Organometallic Compounds - pharmacokinetics Organophosphorus Compounds - pharmacokinetics Papio Pharmacokinetics Radioisotopes - pharmacokinetics Radiopharmaceuticals - pharmacokinetics Samarium - pharmacokinetics Samarium-153 Tissue Distribution Tumors of striated muscle and skeleton
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Zusammenfassung:	Bone-seeking radiopharmaceuticals such as ethylenediaminetetramethylene phosphonate (EDTMP) complexes of samarium-153 and holmium-166 are receiving considerable attention for therapeutic treatment of bone metastases. In this study, using the baboon experimental model, multicompartmental analysis revealed that with regard to pharmacokinetics, biodistribution, and skeletal localisation, 166Ho-EDTMP was significantly inferior to 153Sm-EDTMP and 99mTc-MDP. A more suitable 166Ho-bone-seeking agent should thus be sought for closer similarity to 153Sm-EDTMP to exploit fully the therapeutic potential of its shorter half-life and more energetic beta radiation.
ISSN:	0969-8051 1872-9614
DOI:	10.1016/S0969-8051(96)00117-5