Evaluation of samarium-153 and holmium-166-EDTMP in the normal baboon model

Evaluation of samarium-153 and holmium-166-EDTMP in the normal baboon model

Bone-seeking radiopharmaceuticals such as ethylenediaminetetramethylene phosphonate (EDTMP) complexes of samarium-153 and holmium-166 are receiving considerable attention for therapeutic treatment of bone metastases. In this study, using the baboon experimental model, multicompartmental analysis rev...

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Veröffentlicht in:Nuclear medicine and biology 1996-11, Vol.23 (8), p.935-940
Hauptverfasser: Louw, W.K.A., Dormehl, I.C., van Rensburg, A.J., Hugo, N., Alberts, A.S., Forsyth, O.E., Beverley, G., Sweetlove, M.A., Marais, J., Lötter, M.G., van Aswegen, A.
Format: Artikel
Sprache:eng
Schlagworte:
Absorption
Animals
Baboon model
Biological and medical sciences
Body Fluid Compartments
Bone and Bones - metabolism
Diseases of the osteoarticular system
EDTMP
Evaluation Studies as Topic
Half-Life
Holmium - pharmacokinetics
Holmium-166
Male
Medical sciences
Organometallic Compounds - pharmacokinetics
Organophosphorus Compounds - pharmacokinetics
Papio
Pharmacokinetics
Radioisotopes - pharmacokinetics
Radiopharmaceuticals - pharmacokinetics
Samarium - pharmacokinetics
Samarium-153
Tissue Distribution
Tumors of striated muscle and skeleton
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Beschreibung
Zusammenfassung:Bone-seeking radiopharmaceuticals such as ethylenediaminetetramethylene phosphonate (EDTMP) complexes of samarium-153 and holmium-166 are receiving considerable attention for therapeutic treatment of bone metastases. In this study, using the baboon experimental model, multicompartmental analysis revealed that with regard to pharmacokinetics, biodistribution, and skeletal localisation, 166Ho-EDTMP was significantly inferior to 153Sm-EDTMP and 99mTc-MDP. A more suitable 166Ho-bone-seeking agent should thus be sought for closer similarity to 153Sm-EDTMP to exploit fully the therapeutic potential of its shorter half-life and more energetic beta radiation.
ISSN:0969-8051
1872-9614
DOI:10.1016/S0969-8051(96)00117-5